8A-PDHQ
Chemical compound
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Formula | C15H21N |
Molar mass | 215.340 g·mol−1 |
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8a-Phenyldecahydroquinoline (8A-PDHQ) is a high affinity NMDA antagonist developed by a team at Parke Davis in the 1950s.[1] It is a structural analog of phencyclidine with slightly lower binding affinity than the parent compound. (−)-8a-Phenyldecahydroquinoline has an in vivo potency comparable to that of (+)-MK-801.[2][3]
References
- ^ US Patent 3035059
- ^ Chen C, Kozikowski AP, Wood PL, Reynolds IJ, Ball RG, Pang YP (May 1992). "Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency". Journal of Medicinal Chemistry. 35 (9): 1634–8. doi:10.1021/jm00087a020. PMID 1315871.
- ^ Elhallaoui M, Laguerre M, Carpy A, Ouazzani FC (February 2002). "Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode". Journal of Molecular Modeling. 8 (2): 65–72. doi:10.1007/s00894-001-0067-4. PMID 12032600. S2CID 34882820.
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Hallucinogens
(5-HT2A
agonists)
Benzofurans |
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Phenethyl‐ amines |
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Piperazines | |||||||||||||||||||||||||||||||||||||||||
Tryptamines |
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Others |
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(NMDAR
antagonists)
Arylcyclo‐ hexylamines |
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Adamantanes | |||||||
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Others |
(mAChR
antagonists)
- Atropine
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- BRN-1484501
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- CAR-302,282
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- EA-3167
- EA-3443
- EA-3580
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- Flavoxate
- Hyoscyamine
- JB-318
- JB-336
- Meclozine
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- Oxybutynin
- Pheniramine
- Phenyltoloxamine
- Procyclidine
- Promethazine
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- Tolterodine
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- Tripelennamine
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- WIN-2299
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