ACER2 |
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Identifiers |
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Aliases | ACER2, ALKCDase, ASAH3L, alkalina ceramidasa, ALKCDase2, alkaline ceramidase 2 |
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External IDs | OMIM: 613492; MGI: 1920932; HomoloGene: 14986; GeneCards: ACER2; OMA:ACER2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 9 (human)[1] |
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| Band | 9p22.1 | Start | 19,409,009 bp[1] |
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End | 19,452,505 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 4 (mouse)[2] |
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| Band | 4|4 C4 | Start | 86,792,633 bp[2] |
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End | 86,853,059 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - urinary bladder
- placenta
- subcutaneous adipose tissue
- stomach
- body of stomach
- duodenum
- body of pancreas
- islet of Langerhans
- stromal cell of endometrium
- rectum
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| Top expressed in | - right lung
- right lung lobe
- left lung
- atrium
- left lung lobe
- morula
- aortic valve
- blood
- brown adipose tissue
- ascending aorta
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - dihydroceramidase activity
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
- hydrolase activity
- N-acylsphingosine amidohydrolase activity
- ceramidase activity
- metal ion binding
| Cellular component | - integral component of membrane
- integral component of Golgi membrane
- Golgi apparatus
- membrane
- Golgi membrane
| Biological process | - positive regulation of cell death
- response to retinoic acid
- ceramide metabolic process
- lipid metabolism
- sphingosine biosynthetic process
- sphingolipid biosynthetic process
- negative regulation of cell-matrix adhesion
- positive regulation of cell population proliferation
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of cell adhesion mediated by integrin
- cellular response to DNA damage stimulus
- regulation of autophagy
- DNA damage response, signal transduction by p53 class mediator
- regulation of apoptotic process
- ceramide catabolic process
- sphingolipid metabolic process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_001290541 NM_001290543 NM_139306 NM_028605 |
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RefSeq (protein) | | |
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NP_001277470 NP_001277472 NP_647467 |
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Location (UCSC) | Chr 9: 19.41 – 19.45 Mb | Chr 4: 86.79 – 86.85 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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