ADM2

Protein-coding gene in the species Homo sapiens
ADM2
Identifiers
AliasesADM2, AM2, dJ579N16.4, adrenomedullin 2
External IDsOMIM: 608682; MGI: 2675256; HomoloGene: 49801; GeneCards: ADM2; OMA:ADM2 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for ADM2
Genomic location for ADM2
Band22q13.33Start50,481,543 bp[1]
End50,486,440 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for ADM2
Genomic location for ADM2
Band15|15 E3Start89,206,923 bp[2]
End89,208,934 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • left lobe of thyroid gland

  • stromal cell of endometrium

  • right lobe of thyroid gland

  • duodenum

  • lymph node

  • renal cortex

  • salivary gland

  • bone marrow cells

  • human kidney
Top expressed in
  • zygote

  • secondary oocyte

  • primary oocyte

  • morula

  • embryo

  • embryo

  • calvaria

  • right kidney

  • epiblast

  • blastocyst
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • hormone activity
  • protein-containing complex binding
Cellular component
  • extracellular region
  • intracellular anatomical structure
Biological process
  • digestion
  • protein phosphorylation
  • positive regulation of gene expression
  • adenylate cyclase-activating G protein-coupled receptor signaling pathway
  • angiogenesis
  • feeding behavior
  • positive regulation of angiogenesis
  • negative regulation of blood pressure
  • regulation of signaling receptor activity
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79924

223780

Ensembl

ENSG00000128165

ENSMUSG00000054136

UniProt

Q7Z4H4

Q7TNK8

RefSeq (mRNA)

NM_024866
NM_001253845
NM_001369882

NM_182928

RefSeq (protein)

NP_001240774
NP_001356811

NP_891558

Location (UCSC)Chr 22: 50.48 – 50.49 MbChr 15: 89.21 – 89.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADM2 is a protein that in humans is encoded by the ADM2 gene.[5][6]

ADM2 belongs to a family of calcitonin (MIM 114130)-related peptide hormones important for regulating diverse physiologic functions and the chemical composition of fluids and tissues.[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128165 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054136 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takei Y, Inoue K, Ogoshi M, Kawahara T, Bannai H, Miyano S (Jan 2004). "Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator". FEBS Lett. 556 (1–3): 53–8. doi:10.1016/S0014-5793(03)01368-1. PMID 14706825. S2CID 2063665.
  6. ^ a b "Entrez Gene: ADM2 adrenomedullin 2".

External links

Further reading

  • Kawai M (2004). "[Diagnosis of dermatophytoses: conventional methods and recent molecular biological methods]". Nihon Ishinkin Gakkai Zasshi (Japanese Journal of Medical Mycology). 44 (4): 261–4. doi:10.3314/jjmm.44.261. PMID 14615790.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Roh J, Chang CL, Bhalla A, et al. (2004). "Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes". J. Biol. Chem. 279 (8): 7264–74. doi:10.1074/jbc.M305332200. PMID 14615490.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Takahashi K, Kikuchi K, Maruyama Y, et al. (2006). "Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney". Peptides. 27 (6): 1383–9. doi:10.1016/j.peptides.2005.11.004. PMID 16359754. S2CID 27665694.
  • Kindt F, Wiegand S, Löser C, et al. (2007). "Intermedin: a skin peptide that is downregulated in atopic dermatitis". J. Invest. Dermatol. 127 (3): 605–13. doi:10.1038/sj.jid.5700576. PMID 17008878.
  • Morimoto R, Satoh F, Murakami O, et al. (2007). "Expression of adrenomedullin2/intermedin in human brain, heart, and kidney". Peptides. 28 (5): 1095–103. doi:10.1016/j.peptides.2007.01.018. PMID 17346853. S2CID 23005775.


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