CBL proto-oncogene N-terminal domain 1 (four-helix bundle) |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/4/48/PDB_1b47_EBI.jpg/220px-PDB_1b47_EBI.jpg) structure of the n-terminal domain of cbl in complex with its binding site in zap-70 |
Identifiers |
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Symbol | Cbl_N |
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Pfam | PF02262 |
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InterPro | IPR003153 |
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SCOP2 | 1b47 / SCOPe / SUPFAM |
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Available protein structures: |
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Pfam | structures / ECOD |
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PDB | RCSB PDB; PDBe; PDBj |
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PDBsum | structure summary |
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CBL proto-oncogene N-terminus, EF hand-like domain |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/4/48/PDB_1b47_EBI.jpg/220px-PDB_1b47_EBI.jpg) structure of the n-terminal domain of cbl in complex with its binding site in zap-70 |
Identifiers |
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Symbol | Cbl_N2 |
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Pfam | PF02761 |
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InterPro | IPR014741 |
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SCOP2 | 1b47 / SCOPe / SUPFAM |
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Available protein structures: |
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Pfam | structures / ECOD |
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PDB | RCSB PDB; PDBe; PDBj |
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PDBsum | structure summary |
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CBL proto-oncogene N-terminus, SH2-like domain |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/4/48/PDB_1b47_EBI.jpg/220px-PDB_1b47_EBI.jpg) structure of the n-terminal domain of cbl in complex with its binding site in zap-70 |
Identifiers |
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Symbol | Cbl_N3 |
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Pfam | PF02762 |
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InterPro | IPR014742 |
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SCOP2 | 1b47 / SCOPe / SUPFAM |
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CDD | cd09920 |
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Available protein structures: |
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Pfam | structures / ECOD |
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PDB | RCSB PDB; PDBe; PDBj |
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PDBsum | structure summary |
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In molecular biology, the Cbl TKB domain (tyrosine kinase binding domain), also known as the phosphotyrosine binding (PTB) domain is a conserved region found at the N-terminus of Cbl adaptor proteins. This N-terminal region is composed of three evolutionarily conserved domains: an N-terminal four-helix bundle domain, an EF hand-like domain and a SH2-like domain, which together are known to bind to phosphorylated tyrosine residues.[1][2]
References
- ^ Meng W, Sawasdikosol S, Burakoff SJ, Eck MJ (March 1999). "Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase". Nature. 398 (6722): 84–90. doi:10.1038/18050. PMID 10078535.
- ^ Langenick J, Araki T, Yamada Y, Williams JG (November 2008). "A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling". Journal of Cell Science. 121 (Pt 21): 3524–30. doi:10.1242/jcs.036798. PMID 18840649.
This article incorporates text from the public domain
Pfam and
InterPro: IPR014742
This article incorporates text from the public domain
Pfam and
InterPro: IPR014741
This article incorporates text from the public domain
Pfam and
InterPro: IPR003153