Clometocillin
Chemical compound
- J01CE07 (WHO)
- (2S,5R,6R)-6-([2-(3,4-dichlorophenyl)-2-methoxyacetyl]amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- 1926-49-4
- 71807
- 64831
- YI8LL014GF
- D07236
- CHEBI:131732
- ChEMBL2106548
- DTXSID20172859
- Interactive image
- O=C(O)[C@@H]2N3C(=O)[C@@H](NC(=O)C(OC)c1ccc(Cl)c(Cl)c1)[C@H]3SC2(C)C
Clometocillin (or clometacillin) is a penicillin.[1][2]
References
- ^ Vanhoof R (September 1998). "Comparative in-vitro activities of amoxycillin and penicillin against Streptococcus pneumoniae isolates". The Journal of Antimicrobial Chemotherapy. 42 (3): 397–8. doi:10.1093/jac/42.3.397. PMID 9786482.
- ^ "Clometocillin". Pharmaceutical Manufacturing Encyclopedia (3rd ed.). Norwich, N.Y.: William Andrew Publishing. 2007. p. 1091. ISBN 978-0-8155-1856-3.
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(inhibit synthesis
of peptidoglycan
layer of bacterial
cell wall by binding
to and inhibiting
PBPs, a group of
D-alanyl-D-alanine
transpeptidases)
Glycopeptides Lipoglycopeptides |
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Lipopeptides |
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Polymyxins |
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Other |
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- Inhibit PG subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
- Hydrolyze NAM-NAG
- Tyrothricin
- Isoniazid#
- Teixobactin
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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