DCAF8

Protein-coding gene in the species Homo sapiens
DCAF8
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3I8E

Identifiers
AliasesDCAF8, GAN2, H326, WDR42A, DDB1 and CUL4 associated factor 8
External IDsOMIM: 615820; MGI: 91860; HomoloGene: 56725; GeneCards: DCAF8; OMA:DCAF8 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for DCAF8
Genomic location for DCAF8
Band1q23.2Start160,215,715 bp[1]
End160,262,549 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for DCAF8
Genomic location for DCAF8
Band1 H3|1 79.54 cMStart171,975,651 bp[2]
End172,024,572 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • right lobe of thyroid gland

  • gastric mucosa

  • body of pancreas

  • sural nerve

  • left lobe of thyroid gland

  • right hemisphere of cerebellum

  • right ovary

  • Achilles tendon

  • left ovary
Top expressed in
  • neural layer of retina

  • muscle of thigh

  • ventricular zone

  • dentate gyrus of hippocampal formation granule cell

  • zygote

  • aortic valve

  • ascending aorta

  • right kidney

  • spermatocyte

  • primary oocyte
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • nucleoplasm
  • mitochondrion
  • cytosol
  • cytoplasm
  • Cul4-RING E3 ubiquitin ligase complex
  • nucleus
Biological process
  • post-translational protein modification
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

50717

98193

Ensembl

ENSG00000132716

ENSMUSG00000026554

UniProt

Q5TAQ8
Q5TAQ9

Q8N7N5

RefSeq (mRNA)

NM_015726

NM_153555
NM_001357204

RefSeq (protein)

NP_056541

NP_705783
NP_001344133

Location (UCSC)Chr 1: 160.22 – 160.26 MbChr 1: 171.98 – 172.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DDB1 and CUL4 associated factor 8 is a protein that in humans is encoded by the DCAF8 gene. [5]

Function

This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132716 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026554 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: DDB1 and CUL4 associated factor 8". Retrieved 2018-08-23.

Further reading

  • Li M, Wang L, Ren X, Zheng C (June 2011). "Host cell targets of tegument protein VP22 of herpes simplex virus 1". Arch. Virol. 156 (6): 1079–84. doi:10.1007/s00705-011-0960-9. PMID 21424732. S2CID 10554037.
  • Wu F, Wang S, Xing J, Li M, Zheng C (April 2012). "Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A)". FEBS Lett. 586 (8): 1079–85. doi:10.1016/j.febslet.2012.02.053. PMID 22500989.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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