Desmethoxyfallypride

Chemical compound
  • none
Identifiers
  • 5-(3-fluoropropyl)-2-methoxy-N-[[(2S)-1-prop-2-enylpyrrolidin-2-yl]methyl]benzamide
CAS Number
  • 166173-81-5
PubChem CID
  • 10404663
ChemSpider
  • 8580101
UNII
  • CJD4EF9EME
ChEMBL
  • ChEMBL428561
Chemical and physical dataFormulaC19H27FN2O2Molar mass334.435 g·mol−13D model (JSmol)
  • Interactive image
  • COC1=C(C=C(C=C1)CCCF)C(=O)NC[C@@H]2CCCN2CC=C
InChI
  • InChI=1S/C19H27FN2O2/c1-3-11-22-12-5-7-16(22)14-21-19(23)17-13-15(6-4-10-20)8-9-18(17)24-2/h3,8-9,13,16H,1,4-7,10-12,14H2,2H3,(H,21,23)/t16-/m0/s1
  • Key:VPBJNBUDASILSQ-INIZCTEOSA-N

Desmethoxyfallypride is a moderate affinity dopamine D2 receptor/D3 receptor antagonist used in medical research, usually in the form of the radiopharmaceutical [F-18]-desmethoxyfallypride (DMFP(18F))[1][2] which has been used in human studies as a positron emission tomography (PET) radiotracer.[3][4]

References

  1. ^ Mukherjee J, Yang ZY, Brown T, Roemer J, Cooper M (1996). "18F-desmethoxyfallypride: a fluorine-18 labeled radiotracer with properties similar to carbon-11 raclopride for PET imaging studies of dopamine D2 receptors". Life Sciences. 59 (8): 669–78. doi:10.1016/0024-3205(96)00348-7. PMID 8761017.
  2. ^ Leung, K. (2004). "(S)-N-((1-Allyl-2-pyrrolidinyl)methyl)-5-(3-[18F]fluoropropyl)-2-methoxybenzamide". Molecular Imaging and Contrast Agent Database. PMID 20641474.
  3. ^ Gründer G, Siessmeier T, Piel M, Vernaleken I, Buchholz HG, Zhou Y, et al. (January 2003). "Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride". Journal of Nuclear Medicine. 44 (1): 109–16. PMID 12515884.
  4. ^ Siessmeier T, Zhou Y, Buchholz HG, Landvogt C, Vernaleken I, Piel M, et al. (June 2005). "Parametric mapping of binding in human brain of D2 receptor ligands of different affinities". Journal of Nuclear Medicine. 46 (6): 964–72. PMID 15937307.
  • v
  • t
  • e
Dopamine receptor modulators
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists
  • See also: Receptor/signaling modulators
  • Adrenergics
  • Serotonergics
  • Monoamine reuptake inhibitors
  • Monoamine releasing agents
  • Monoamine metabolism modulators
  • Monoamine neurotoxins


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