EDEM1

Protein-coding gene in the species Homo sapiens
EDEM1
Identifiers
AliasesEDEM1, EDEM, ER degradation enhancing alpha-mannosidase like protein 1
External IDsOMIM: 607673; MGI: 2180139; HomoloGene: 33836; GeneCards: EDEM1; OMA:EDEM1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for EDEM1
Genomic location for EDEM1
Band3p26.1Start5,187,646 bp[1]
End5,219,958 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for EDEM1
Genomic location for EDEM1
Band6|6 E2Start108,805,602 bp[2]
End108,836,317 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bone marrow cells

  • thymus

  • liver

  • right lobe of liver

  • lymph node

  • appendix

  • thymus

  • stromal cell of endometrium

  • monocyte

  • trabecular bone
Top expressed in
  • lacrimal gland

  • thymus

  • parotid gland

  • crypt of lieberkuhn of small intestine

  • left lobe of liver

  • submandibular gland

  • islet of Langerhans

  • seminal vesicula

  • jejunum

  • pyloric antrum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • calcium ion binding
  • misfolded protein binding
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
  • protein binding
  • catalytic activity
Cellular component
  • integral component of membrane
  • endoplasmic reticulum membrane
  • membrane
  • integral component of endoplasmic reticulum membrane
  • endoplasmic reticulum
  • endoplasmic reticulum quality control compartment
  • Golgi membrane
  • aggresome
Biological process
  • N-glycan processing
  • positive regulation of retrograde protein transport, ER to cytosol
  • trimming of terminal mannose on C branch
  • IRE1-mediated unfolded protein response
  • response to unfolded protein
  • ubiquitin-dependent glycoprotein ERAD pathway
  • mannose trimming involved in glycoprotein ERAD pathway
  • ubiquitin-dependent ERAD pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9695

192193

Ensembl

ENSG00000134109

ENSMUSG00000030104

UniProt

Q92611

Q925U4

RefSeq (mRNA)

NM_014674

NM_138677

RefSeq (protein)

NP_055489

NP_619618

Location (UCSC)Chr 3: 5.19 – 5.22 MbChr 6: 108.81 – 108.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ER degradation-enhancing alpha-mannosidase-like 1 is an enzyme that in humans is encoded by the EDEM1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134109 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030104 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Molinari M, Calanca V, Galli C, Lucca P, Paganetti P (Feb 2003). "Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle". Science. 299 (5611): 1397–400. doi:10.1126/science.1079474. PMID 12610306. S2CID 24092303.
  6. ^ "Entrez Gene: EDEM1 ER degradation enhancer, mannosidase alpha-like 1".

Further reading

  • Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  • Hosokawa N, Wada I, Hasegawa K, et al. (2001). "A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation". EMBO Rep. 2 (5): 415–22. doi:10.1093/embo-reports/kve084. PMC 1083879. PMID 11375934.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Oda Y, Hosokawa N, Wada I, Nagata K (2003). "EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin". Science. 299 (5611): 1394–7. doi:10.1126/science.1079181. PMID 12610305. S2CID 28716209.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Olivari S, Galli C, Alanen H, et al. (2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J. Biol. Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
  • Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation". J. Cell Biol. 172 (3): 383–93. doi:10.1083/jcb.200507057. PMC 2063648. PMID 16449189.
  • Hosokawa N, Wada I, Natsuka Y, Nagata K (2006). "EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha1-antitrypsin". Genes Cells. 11 (5): 465–76. doi:10.1111/j.1365-2443.2006.00957.x. PMID 16629899. S2CID 19832510.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Zuber C, Cormier JH, Guhl B, et al. (2007). "EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites". Proc. Natl. Acad. Sci. U.S.A. 104 (11): 4407–12. Bibcode:2007PNAS..104.4407Z. doi:10.1073/pnas.0700154104. PMC 1810509. PMID 17360537.


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