Protein-coding gene in the species Homo sapiens
FAM114A2 |
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Identifiers |
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Aliases | FAM114A2, 133K02, C5orf3, family with sequence similarity 114 member A2 |
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External IDs | MGI: 1917629; HomoloGene: 10270; GeneCards: FAM114A2; OMA:FAM114A2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 5 (human)[1] |
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| Band | 5q33.2 | Start | 153,990,148 bp[1] |
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End | 154,038,936 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11|11 B1.3 | Start | 57,373,819 bp[2] |
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End | 57,409,443 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - epithelium of colon
- Achilles tendon
- secondary oocyte
- sperm
- testicle
- Epithelium of choroid plexus
- islet of Langerhans
- body of pancreas
- left testis
- right testis
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| Top expressed in | - seminal vesicula
- condyle
- Rostral migratory stream
- muscle of thigh
- granulocyte
- neural layer of retina
- ganglionic eminence
- saccule
- lacrimal gland
- vestibular sensory epithelium
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - purine nucleotide binding
| Cellular component | | Biological process | | Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_018691 NM_001317993 NM_001317994 NM_001317995 |
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NM_001168667 NM_001168668 NM_026342 |
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RefSeq (protein) | |
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NP_001304922 NP_001304923 NP_001304924 NP_061161 |
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NP_001162138 NP_001162139 NP_080618 |
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Location (UCSC) | Chr 5: 153.99 – 154.04 Mb | Chr 11: 57.37 – 57.41 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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FAM114A2 (chromosome 5 open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. The protein function is not well known. FAM114A2 is, however, highly conserved in mammals with homologs both in fungi and plants.
Protein
The FAM114A2 protein is 505 amino acids long[5] with a molecular weight of 55.5 kdal and an isoelectric point of 4.66.[6] It is predicted to stay in the nucleus after translation [7] There is evidence that c5orf3 interacts with another protein of unknown function from chromosome 5, c5orf4 [8] This protein is thought to include a P loop[9] that suggests a role in ATP- and/or GTP-binding [10]
Gene
The FAM114A2 gene is located on chromosome 5 (5q31-33).[11] This gene has 14 exons spanning through its sequence.[5] The coding sequence is 2886 base pairs with a 5’ UTR of 94 base pairs and a 3’ UTR of 1273 base pairs.[5] It is expressed at high levels in most tissues of the human body.[11] It is also highly expressed in tissues in the human brain [12]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000055147 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020523 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c Homo sapiens family with sequence similarity 114, member A2 (FAM114A2) - Nucleotide - NCBI
- ^ Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi#[permanent dead link]!
- ^ PSORT WWW Server
- ^ STRING: http://string-db.org/newstring_cgi/show_network_section.pl.
- ^ "STRING: Functional protein association networks".
- ^ Saraste M, Sibbald PR, Wittinghofer A (November 1990). "The P-loop--a common motif in ATP- and GTP-binding proteins". Trends Biochem. Sci. 15 (11): 430–4. doi:10.1016/0968-0004(90)90281-f. PMID 2126155.
- ^ a b FAM114A2 Gene - GeneCards | F1142 Protein | F1142 Antibody
- ^ Allen Brain Atlas: http://human.brain-map.org/search?type=mi Archived 2011-08-18 at the Wayback Machine
External links
Further reading
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.