Protein-coding gene in the species Homo sapiens
GBP6 |
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Identifiers |
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Aliases | GBP6, guanylate binding protein family member 6 |
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External IDs | OMIM: 612467; MGI: 97072; HomoloGene: 128731; GeneCards: GBP6; OMA:GBP6 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 1 (human)[1] |
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| Band | 1p22.2 | Start | 89,364,059 bp[1] |
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End | 89,388,160 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 5 (mouse)[2] |
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| Band | 5 E5|5 50.68 cM | Start | 105,263,633 bp[2] |
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End | 105,287,452 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gingival epithelium
- mucosa of pharynx
- oral cavity
- mucosa of esophagus
- body of tongue
- superior surface of tongue
- epithelium of nasopharynx
- tonsil
- vulva
- vagina
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| Top expressed in | - thymus
- spleen
- lung
- heart
- pancreas
- islet of Langerhans
- jejunum
- ileum
- muscle tissue
- ovary
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - nucleotide binding
- GTP binding
- GTPase activity
| Cellular component | - extracellular exosome
- symbiont-containing vacuole membrane
- cytoplasmic vesicle
| Biological process | - defense response to bacterium
- immune response
- cellular response to interferon-gamma
- defense response to protozoan
- defense response to Gram-positive bacterium
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | NM_001256005 NM_008620 NM_001359079 NM_001359080 NM_001359081
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NM_001359082 |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 89.36 – 89.39 Mb | Chr 5: 105.26 – 105.29 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Guanylate binding protein family member 6 is a protein that in humans is encoded by the GBP6 gene. [5]
Function
Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000183347 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079363 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Guanylate binding protein family member 6". Retrieved 2017-07-27.
Further reading
- Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.