Guanylate binding protein family member 6

Protein-coding gene in the species Homo sapiens
GBP6
Identifiers
AliasesGBP6, guanylate binding protein family member 6
External IDsOMIM: 612467; MGI: 97072; HomoloGene: 128731; GeneCards: GBP6; OMA:GBP6 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GBP6
Genomic location for GBP6
Band1p22.2Start89,364,059 bp[1]
End89,388,160 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for GBP6
Genomic location for GBP6
Band5 E5|5 50.68 cMStart105,263,633 bp[2]
End105,287,452 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gingival epithelium

  • mucosa of pharynx

  • oral cavity

  • mucosa of esophagus

  • body of tongue

  • superior surface of tongue

  • epithelium of nasopharynx

  • tonsil

  • vulva

  • vagina
Top expressed in
  • thymus

  • spleen

  • lung

  • heart

  • pancreas

  • islet of Langerhans

  • jejunum

  • ileum

  • muscle tissue

  • ovary
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • GTPase activity
Cellular component
  • extracellular exosome
  • symbiont-containing vacuole membrane
  • cytoplasmic vesicle
Biological process
  • defense response to bacterium
  • immune response
  • cellular response to interferon-gamma
  • defense response to protozoan
  • defense response to Gram-positive bacterium
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

163351

17472

Ensembl

ENSG00000183347

ENSMUSG00000079363

UniProt

Q6ZN66

n/a

RefSeq (mRNA)

NM_198460
NM_001320257

NM_001256005
NM_008620
NM_001359079
NM_001359080
NM_001359081

NM_001359082

RefSeq (protein)

NP_001307186
NP_940862

n/a

Location (UCSC)Chr 1: 89.36 – 89.39 MbChr 5: 105.26 – 105.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanylate binding protein family member 6 is a protein that in humans is encoded by the GBP6 gene. [5]

Function

Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183347 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079363 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Guanylate binding protein family member 6". Retrieved 2017-07-27.

Further reading

  • Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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