HEMGN

Protein-coding gene in the species Homo sapiens
HEMGN
Identifiers
AliasesHEMGN, CT155, EDAG, EDAG-1, NDR, hemogen
External IDsOMIM: 610715; MGI: 2136910; HomoloGene: 14223; GeneCards: HEMGN; OMA:HEMGN - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for HEMGN
Genomic location for HEMGN
Band9q22.33Start97,926,791 bp[1]
End97,944,856 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for HEMGN
Genomic location for HEMGN
Band4|4 B1Start46,393,989 bp[2]
End46,413,506 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • trabecular bone

  • sperm

  • bone marrow

  • bone marrow cells

  • monocyte

  • right testis

  • left testis

  • blood

  • testicle

  • ganglionic eminence
Top expressed in
  • fetal liver hematopoietic progenitor cell

  • tibiofemoral joint

  • human fetus

  • body of femur

  • spleen

  • right lobe of liver

  • blood

  • bone marrow

  • tail of embryo

  • yolk sac
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • multicellular organism development
  • cell differentiation
  • regulation of osteoblast differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55363

93966

Ensembl

ENSG00000136929

ENSMUSG00000028332

UniProt

Q9BXL5

Q9ERZ0

RefSeq (mRNA)

NM_018437
NM_197978

NM_053149

RefSeq (protein)

NP_060907
NP_932095

NP_444379

Location (UCSC)Chr 9: 97.93 – 97.94 MbChr 4: 46.39 – 46.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hemogen is a protein that in humans is encoded by the HEMGN gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136929 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028332 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: HEMGN hemogen".

Further reading

  • Yang LV, Nicholson RH, Kaplan J, et al. (2001). "Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms". Mech. Dev. 104 (1–2): 105–11. doi:10.1016/S0925-4773(01)00376-8. PMID 11404085. S2CID 2968450.
  • Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yang LV, Heng HH, Wan J, et al. (2004). "Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis". Dev. Dyn. 228 (4): 606–16. doi:10.1002/dvdy.10399. PMID 14648837. S2CID 26030697.
  • Liu CC, Chou YL, Ch'ang LY (2004). "Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells". J. Biomed. Sci. 11 (1): 104–16. doi:10.1159/000075293. PMID 14730214. S2CID 202650770.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Li CY, Zhan YQ, Xu CW, et al. (2005). "EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B". Cell Death Differ. 11 (12): 1299–308. doi:10.1038/sj.cdd.4401490. PMID 15332117.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • An LL, Li G, Wu KF, et al. (2005). "High expression of EDAG and its significance in AML". Leukemia. 19 (8): 1499–502. doi:10.1038/sj.leu.2403808. PMID 15920494. S2CID 5280303.
  • Yang LV, Wan J, Ge Y, et al. (2006). "The GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cells". Leukemia. 20 (3): 417–25. doi:10.1038/sj.leu.2404105. PMID 16437149. S2CID 9613437.
  • Ling B, Zhou Y, Feng D, et al. (2007). "Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells". Oncol. Rep. 18 (3): 659–64. doi:10.3892/or.18.3.659. PMID 17671716.


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