HMGXB4

Protein-coding gene in the species Homo sapiens
HMGXB4
Identifiers
AliasesHMGXB4, Hmgxb4, 4733401K04Rik, AI316803, E430025G12, Hmgb2l1, HMG2L1, HMGBCG, THC211630, HMG-box containing 4, P53N
External IDsOMIM: 604702; MGI: 1918073; HomoloGene: 4007; GeneCards: HMGXB4; OMA:HMGXB4 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for HMGXB4
Genomic location for HMGXB4
Band22q12.3Start35,257,452 bp[1]
End35,295,807 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for HMGXB4
Genomic location for HMGXB4
Band8|8 C1Start75,719,984 bp[2]
End75,758,606 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • buccal mucosa cell

  • sperm

  • sural nerve

  • testicle

  • ventricular zone

  • gonad

  • placenta

  • tibia
Top expressed in
  • zygote

  • secondary oocyte

  • genital tubercle

  • tail of embryo

  • primary oocyte

  • Rostral migratory stream

  • ventricular zone

  • primitive streak

  • medullary collecting duct

  • morula
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
Cellular component
  • NURF complex
  • nucleus
Biological process
  • negative regulation of Wnt signaling pathway
  • Wnt signaling pathway
  • endosome to lysosome transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10042

70823

Ensembl

ENSG00000100281

ENSMUSG00000034518

UniProt

Q9UGU5

n/a

RefSeq (mRNA)

NM_001003681
NM_005487
NM_014250
NM_001362972

NM_178017
NM_001316753
NM_001316754

RefSeq (protein)

NP_001003681
NP_001349901

n/a

Location (UCSC)Chr 22: 35.26 – 35.3 MbChr 8: 75.72 – 75.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HMG-box containing 4 is a protein that in humans is encoded by the HMGXB4 gene. [5]

Function

High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100281 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034518 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: HMG-box containing 4". Retrieved 2017-11-17.

Further reading

  • Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR, Feinberg AP, McMahon FJ (2008). "Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1". Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (1): 59–67. doi:10.1002/ajmg.b.30574. PMID 17671966.
  • Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR, Feinberg AP, McMahon FJ (2008). "Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1". Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (1): 59–67. doi:10.1002/ajmg.b.30574. PMID 17671966.
  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Zhou J, Hu G, Wang X (2010). "Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1". J. Biol. Chem. 285 (30): 23177–85. doi:10.1074/jbc.M110.109868. PMC 2906311. PMID 20511232.
  • Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (2010). "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutat. Res. 694 (1–2): 13–9. doi:10.1016/j.mrfmmm.2010.08.006. PMID 20800603.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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