HP1BP3

Protein-coding gene in the species Homo sapiens
HP1BP3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2RQP

Identifiers
AliasesHP1BP3, HP1-BP74, HP1BP74, heterochromatin protein 1 binding protein 3
External IDsOMIM: 616072; MGI: 109369; HomoloGene: 7774; GeneCards: HP1BP3; OMA:HP1BP3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HP1BP3
Genomic location for HP1BP3
Band1p36.12Start20,742,679 bp[1]
End20,787,323 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for HP1BP3
Genomic location for HP1BP3
Band4|4 D3Start137,943,607 bp[2]
End137,971,994 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 23

  • ventricular zone

  • tibia

  • trabecular bone

  • parietal pleura

  • visceral pleura

  • skin of hip

  • Achilles tendon

  • parotid gland

  • seminal vesicula
Top expressed in
  • renal corpuscle

  • medullary collecting duct

  • ventricular zone

  • condyle

  • ascending aorta

  • aortic valve

  • neural layer of retina

  • ganglionic eminence

  • vestibular membrane of cochlear duct

  • thymus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • nucleosome binding
  • protein binding
  • chromatin binding
Cellular component
  • nucleosome
  • nucleus
  • chromosome
  • nuclear speck
Biological process
  • regulation of nucleus size
  • nucleosome assembly
  • heterochromatin organization
  • regulation of transcription, DNA-templated
  • regulation of cell population proliferation
  • cellular response to hypoxia
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

50809

15441

Ensembl

ENSG00000127483

ENSMUSG00000028759

UniProt

Q5SSJ5

Q3TEA8

RefSeq (mRNA)

NM_016287
NM_001372052

NM_001122896
NM_001122897
NM_001285478
NM_001285479
NM_001285480

NM_001285481
NM_010470
NM_001356431
NM_001356432

RefSeq (protein)
NP_057371
NP_001358981
NP_001363716
NP_001363717
NP_001363718

NP_001363719
NP_001363720
NP_001363721
NP_001363722
NP_001363723
NP_001363724
NP_001363725
NP_001363726

NP_001116368
NP_001116369
NP_001272407
NP_001272408
NP_001272409

NP_001272410
NP_034600
NP_001343360
NP_001343361

Location (UCSC)Chr 1: 20.74 – 20.79 MbChr 4: 137.94 – 137.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heterochromatin protein 1, binding protein 3 is a protein that in humans is encoded by the HP1BP3 gene.[5] It has been identified as a novel subtype of the linker histone H1, involved in the structure of heterochromatin [6][7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127483 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028759 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: heterochromatin protein 1, binding protein 3". Retrieved 2011-08-30.
  6. ^ Garfinkel BP, Melamed-Book N, Anuka E, Bustin M, Orly J (February 2015). "HP1BP3 is a novel histone H1 related protein with essential roles in viability and growth". Nucleic Acids Research. 43 (4): 2074–90. doi:10.1093/nar/gkv089. PMC 4344522. PMID 25662603.
  7. ^ Dutta B, Ren Y, Hao P, Sim KH, Cheow E, Adav S, Tam JP, Sze SK (September 2014). "Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression". Molecular & Cellular Proteomics. 13 (9): 2183–97. doi:10.1074/mcp.M113.034975. PMC 4159643. PMID 24830416.
  8. ^ Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K (February 2010). "The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA". The Journal of Biological Chemistry. 285 (9): 6498–507. doi:10.1074/jbc.M109.092833. PMC 2825445. PMID 20042602.

Further reading

  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Ouyang J, Shi Y, Valin A, Xuan Y, Gill G (April 2009). "Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex". Molecular Cell. 34 (2): 145–54. doi:10.1016/j.molcel.2009.03.013. PMC 2727917. PMID 19394292.
  • Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW (April 2009). "Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia". European Archives of Psychiatry and Clinical Neuroscience. 259 (3): 151–63. doi:10.1007/s00406-008-0847-2. PMID 19165527. S2CID 33815571.
  • Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (December 2010). "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutation Research. 694 (1–2): 13–9. doi:10.1016/j.mrfmmm.2010.08.006. PMID 20800603.
  • Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K (February 2010). "The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA". The Journal of Biological Chemistry. 285 (9): 6498–507. doi:10.1074/jbc.M109.092833. PMC 2825445. PMID 20042602.
  • Gautier VW, Gu L, O'Donoghue N, Pennington S, Sheehy N, Hall WW (2009). "In vitro nuclear interactome of the HIV-1 Tat protein". Retrovirology. 6: 47. doi:10.1186/1742-4690-6-47. PMC 2702331. PMID 19454010.