Histone cluster 2 h3 family member d

H3C13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IIJ, 2X4W, 2X4X, 2X4Y, 3AV1, 3DB3, 3MO8, 3R93, 4MZF, 4MZG, 4MZH, 4OUC, 5BO0, 2HIO, 5B0Z, 2ARO, 1EQZ, 1HQ3, 4KGC, 1TZY, 4UUZ, 2F8N, 5B0Y, 4LD9, 5B40, 5CIU
Identifiers
Aliases	H3C13, histone cluster 2 H3 family member d, H3 clustered histone 13, HIST2H3D, H3C15, H3C14
External IDs	MGI: 2448320; HomoloGene: 134489; GeneCards: H3C13; OMA:H3C13 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 149,813,225 bp[1] End 149,813,693 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 23,928,956 bp[2] End 23,929,585 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells testicle Achilles tendon blood right ovary granulocyte left ovary fundus corpus callosum right adrenal cortex Top expressed in uterus embryo ventricular zone spermatid embryo spermatocyte bone marrow mesencephalon yolk sac tail of embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein heterodimerization activity DNA binding histone binding protein binding chromatin binding nucleosomal DNA binding Cellular component extracellular exosome extracellular region nucleoplasm chromosome nucleosome nucleus chromatin Biological process epigenetic maintenance of chromatin in transcription-competent conformation blood coagulation rDNA heterochromatin assembly nucleosome assembly negative regulation of gene expression, epigenetic negative regulation of transcription by RNA polymerase II chromatin organization regulation of gene silencing by miRNA interleukin-7-mediated signaling pathway regulation of megakaryocyte differentiation regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 653604 319148 Ensembl ENSG00000183598 ENSMUSG00000069310 UniProt Q71DI3 P84228 RefSeq (mRNA) NM_001123375 NM_175653 RefSeq (protein) NP_066403 NP_001116847 NP_473386 NP_835734 NP_783584 NP_835510 NP_835587 NP_038576 NP_835511 NP_835512 Location (UCSC) Chr 1: 149.81 – 149.81 Mb Chr 13: 23.93 – 23.93 Mb PubMed search [3] [4]
Wikidata
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Histone cluster 2 H3 family member d is a protein that in humans is encoded by the HIST2H3D gene. ^[5]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. [provided by RefSeq, Aug 2015].

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.