Hydroxyacid oxidase 2

Protein-coding gene in the species Homo sapiens
HAO2
Identifiers
AliasesHAO2, GIG16, HAOX2, hydroxyacid oxidase 2
External IDsOMIM: 605176; MGI: 96012; HomoloGene: 97412; GeneCards: HAO2; OMA:HAO2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HAO2
Genomic location for HAO2
Band1p12Start119,368,779 bp[1]
End119,394,130 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for HAO2
Genomic location for HAO2
Band3 F2.2|3 42.9 cMStart98,781,837 bp[2]
End98,800,555 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • kidney tubule

  • glomerulus

  • metanephric glomerulus

  • human kidney

  • testicle

  • renal medulla

  • skin of thigh

  • skin of arm

  • vulva
Top expressed in
  • left colon

  • adrenal gland

  • proximal tubule

  • human kidney

  • right kidney

  • Gonadal ridge

  • migratory enteric neural crest cell

  • adrenal medulla

  • epithelium of small intestine

  • ileum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • (S)-2-hydroxy-acid oxidase activity
  • oxidoreductase activity
  • FMN binding
  • signaling receptor binding
  • catalytic activity
Cellular component
  • peroxisome
  • peroxisomal matrix
  • cytosol
Biological process
  • fatty acid oxidation
  • fatty acid catabolic process
  • protein targeting to peroxisome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51179

56185

Ensembl

ENSG00000116882

ENSMUSG00000027870

UniProt

Q9NYQ3

Q9NYQ2

RefSeq (mRNA)

NM_001005783
NM_016527

NM_019545

RefSeq (protein)

NP_001005783
NP_057611
NP_001364401

NP_062418

Location (UCSC)Chr 1: 119.37 – 119.39 MbChr 3: 98.78 – 98.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hydroxyacid oxidase 2 is a protein that in humans is encoded by the HAO2 gene. [5]

Function

This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116882 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027870 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Hydroxyacid oxidase 2". Retrieved 2016-07-03.

Further reading

  • Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N (2010). "Genetic susceptibility to distinct bladder cancer subphenotypes". Eur. Urol. 57 (2): 283–92. doi:10.1016/j.eururo.2009.08.001. PMC 3220186. PMID 19692168.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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