IPO4

Protein-coding gene in the species Homo sapiens
IPO4
Identifiers
AliasesIPO4, Imp4, importin 4
External IDsMGI: 1923001; HomoloGene: 5835; GeneCards: IPO4; OMA:IPO4 - orthologs
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[1]
Chromosome 14 (mouse)
Genomic location for IPO4
Genomic location for IPO4
Band14 C3|14 28.19 cMStart55,862,857 bp[1]
End55,873,414 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • gastrocnemius muscle

  • right uterine tube

  • right adrenal gland

  • sural nerve

  • anterior pituitary

  • left adrenal gland

  • kidney

  • skeletal muscle tissue

  • bone marrow cells
Top expressed in
  • internal carotid artery

  • external carotid artery

  • seminiferous tubule

  • fossa

  • Gonadal ridge

  • condyle

  • vas deferens

  • morula

  • arcuate nucleus

  • paraventricular nucleus of hypothalamus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nuclear localization sequence binding
Cellular component
  • cytoplasm
  • nuclear membrane
  • nuclear pore
  • membrane
  • nuclear periphery
  • nucleus
  • protein-containing complex
Biological process
  • protein transport
  • DNA replication-dependent chromatin assembly
  • intracellular protein transport
  • ribosomal protein import into nucleus
  • NLS-bearing protein import into nucleus
  • transport
  • protein import into nucleus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79711

75751

Ensembl

n/a

ENSMUSG00000002319

UniProt

Q8TEX9

Q8VI75

RefSeq (mRNA)

NM_024658

NM_024267
NM_001360078

RefSeq (protein)

NP_078934

NP_077229
NP_001347007

Location (UCSC)n/aChr 14: 55.86 – 55.87 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Importin-4 is a protein that in humans is encoded by the IPO4 gene.[4][5]


References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002319 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Jakel S, Mingot JM, Schwarzmaier P, Hartmann E, Gorlich D (Feb 2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMC 125346. PMID 11823430.
  5. ^ "Entrez Gene: IPO4 importin 4".

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Miyauchi Y, Michigami T, Sakaguchi N, et al. (2006). "Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor". J. Biol. Chem. 280 (49): 40901–8. doi:10.1074/jbc.M509347200. PMID 16207705.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lischka P, Sorg G, Kann M, et al. (2003). "A Nonconventional Nuclear Localization Signal within the UL84 Protein of Human Cytomegalovirus Mediates Nuclear Import via the Importin α/β Pathway". J. Virol. 77 (6): 3734–48. doi:10.1128/JVI.77.6.3734-3748.2003. PMC 149505. PMID 12610148.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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