LARP6

Protein-coding gene in the species Homo sapiens
LARP6
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2MTF, 2MTG

Identifiers
AliasesLARP6, ACHN, La ribonucleoprotein domain family member 6, La ribonucleoprotein 6, translational regulator
External IDsOMIM: 611300; MGI: 1914807; HomoloGene: 32408; GeneCards: LARP6; OMA:LARP6 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for LARP6
Genomic location for LARP6
Band15q23Start70,829,130 bp[1]
End70,854,157 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for LARP6
Genomic location for LARP6
Band9|9 BStart60,620,272 bp[2]
End60,646,084 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • external globus pallidus

  • inferior ganglion of vagus nerve

  • gastric mucosa

  • left testis

  • lateral nuclear group of thalamus

  • right testis

  • C1 segment

  • subthalamic nucleus

  • inferior olivary nucleus

  • pars reticulata
Top expressed in
  • pontine nuclei

  • lateral geniculate nucleus

  • superior colliculus

  • anterior horn of spinal cord

  • deep cerebellar nuclei

  • dorsal tegmental nucleus

  • lateral hypothalamus

  • ventral tegmental area

  • piriform cortex

  • facial motor nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • RNA binding
  • nucleic acid binding
  • protein binding
  • sequence-specific mRNA binding
  • myosin binding
  • RNA stem-loop binding
  • mRNA 5'-UTR binding
Cellular component
  • cytoplasm
  • nucleus
  • polysome
  • ribonucleoprotein complex
Biological process
  • RNA processing
  • regulation of translation
  • positive regulation of collagen biosynthetic process
  • positive regulation of translation
  • positive regulation of mRNA binding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55323

67557

Ensembl

ENSG00000166173

ENSMUSG00000034839

UniProt

Q9BRS8

Q8BN59

RefSeq (mRNA)

NM_197958
NM_001286679
NM_018357

NM_026235

RefSeq (protein)

NP_001273608
NP_060827
NP_932062

NP_080511

Location (UCSC)Chr 15: 70.83 – 70.85 MbChr 9: 60.62 – 60.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

La-related protein 6 also known as acheron or La ribonucleoprotein domain family member 6 (LARP6), is a protein that in humans is encoded by the LARP6 gene.[5]

Clinical relevance

In a recent genome-wide association study, LARP6 gene has been associated with fasting glucose traits, type 2 diabetes and obesity.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166173 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034839 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: La ribonucleoprotein domain family".
  6. ^ Strawbridge RJ, Dupuis J, Prokopenko I, et al. (August 2011). "Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes". Diabetes. 60 (10): 2624–34. doi:10.2337/db11-0415. PMC 3178302. PMID 21873549.

Further reading

  • Cai L, Fritz D, Stefanovic L, Stefanovic B (2010). "Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen". J. Mol. Biol. 395 (2): 309–26. doi:10.1016/j.jmb.2009.11.020. PMC 2826804. PMID 19917293.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Glenn HL, Wang Z, Schwartz LM (2010). "Acheron, a Lupus antigen family member, regulates integrin expression, adhesion, and motility in differentiating myoblasts". Am. J. Physiol., Cell Physiol. 298 (1): C46–55. doi:10.1152/ajpcell.00387.2009. PMC 2806151. PMID 19889961.
  • Valavanis C, Wang Z, Sun D, et al. (2007). "Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta". Gene. 393 (1–2): 101–9. doi:10.1016/j.gene.2007.01.033. PMC 2739619. PMID 17383118.
  • Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.


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