Luzindole
Chemical compound
- None
- In general: non-regulated
- N-[2-(2-benzyl-1H-indol-3-yl)ethyl]acetamide
- 117946-91-5 Y
- 122162
- 108959
- B31Y10A9UR
- CHEBI:131788 Y
- DTXSID40151969
- Interactive image
- O=C(NCCc2c1ccccc1[nH]c2Cc3ccccc3)C
InChI
- InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)
- Key:WVVXBPKOIZGVNS-UHFFFAOYSA-N
Luzindole (N-0774), (N-acetyl-2-benzyltryptamine), is a drug used in scientific research to study the role of melatonin in the body. Luzindole acts as a selective melatonin receptor antagonist,[1] with approximately 11- to 25-fold greater affinity for the MT2 over the MT1 receptor.[2][3] In animal studies, it has been observed to disrupt the circadian rhythm as well as produce antidepressant effects.[2][4]
References
- ^ Dubocovich ML (September 1988). "Luzindole (N-0774): a novel melatonin receptor antagonist". The Journal of Pharmacology and Experimental Therapeutics. 246 (3): 902–10. PMID 2843633.
- ^ a b Dubocovich ML, Yun K, Al-Ghoul WM, Benloucif S, Masana MI (September 1998). "Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms". The FASEB Journal. 12 (12): 1211–20. doi:10.1096/fasebj.12.12.1211. PMID 9737724. S2CID 566199.
- ^ Browning C, Beresford I, Fraser N, Giles H (March 2000). "Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors". British Journal of Pharmacology. 129 (5): 877–86. doi:10.1038/sj.bjp.0703130. PMC 1571913. PMID 10696085.
- ^ Dubocovich ML, Mogilnicka E, Areso PM (July 1990). "Antidepressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in the mouse behavioral despair test". European Journal of Pharmacology. 182 (2): 313–25. doi:10.1016/0014-2999(90)90290-M. PMID 2168835.
- v
- t
- e
- Agonists: 2-Iodomelatonin
- 6-Hydroxymelatonin
- Agomelatine
- Fabomotizole (afobazole)
- GR-196,429
- Melatonin
- N-Acetylserotonin (normelatonin)
- Piromelatine
- Ramelteon
- Tasimelteon
- TIK-301 (LY-156,735)
- Antagonists: Luzindole
- Agonists: 2-Iodomelatonin
- 6-Hydroxymelatonin
- Agomelatine
- GR-196,429
- Melatonin
- N-Acetylserotonin (normelatonin)
- Piromelatine
- Ramelteon
- Tasimelteon
- TIK-301 (LY-156,735)
- Antagonists: Luzindole
- Agonists: 2-Phenylmelatonin
- 5-Methoxyluzindole
- 6-Chloromelatonin
- 6-Fluoromelatonin
- 6-Methoxymelatonin
- 6,7-Dichloro-2-methylmelatonin
- 8-M-PDOT
- AMMTC
- GR-135,531 (of MT3Tooltip melatonin receptor 1C)
- N-Acetyltryptamine
- N-Butanoylmelatonin
- N-Propionylmelatonin
- S-24268
- S-25150
- Antagonists: 4-P-ADOT
- 4-P-PDOT
- DH-97
- N-Acetyltryptamine (of MT3)
- Prazosin (of MT3)
- S-20928
- S-22153
- S-24601
- S-25567
- S-26131
- See also: Receptor/signaling modulators
- Adrenergics
- Dopaminergics
- Serotonergics
- Monoamine metabolism modulators