MAB21L2

Protein-coding gene in the species Homo sapiens
MAB21L2
Identifiers
AliasesMAB21L2, MCOPS14, Mab-21-like 2 (C. elegans), mab-21 like 2, MCSKS14
External IDsOMIM: 604357; MGI: 1346022; HomoloGene: 7824; GeneCards: MAB21L2; OMA:MAB21L2 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for MAB21L2
Genomic location for MAB21L2
Band4q31.3Start150,582,151 bp[1]
End150,584,693 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for MAB21L2
Genomic location for MAB21L2
Band3|3 F1Start86,452,888 bp[2]
End86,455,936 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle layer of sigmoid colon

  • pons

  • retinal pigment epithelium

  • dorsal motor nucleus of vagus nerve

  • synovial joint

  • superior vestibular nucleus

  • transverse colon

  • Achilles tendon

  • cecum

  • optic nerve
Top expressed in
  • maxillary prominence

  • mandibular prominence

  • abdominal wall

  • superior cervical ganglion

  • hand

  • lens

  • medial vestibular nucleus

  • neural layer of retina

  • iris

  • embryonic cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • nucleus
  • cytoplasm
Biological process
  • eye development
  • multicellular organism development
  • camera-type eye development
  • nervous system development
  • positive regulation of cell population proliferation
  • embryonic body morphogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10586

23937

Ensembl

ENSG00000181541

ENSMUSG00000057777

UniProt

Q9Y586

Q8BPP1

RefSeq (mRNA)

NM_006439

NM_011839

RefSeq (protein)

NP_006430

NP_035969

Location (UCSC)Chr 4: 150.58 – 150.58 MbChr 3: 86.45 – 86.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mab-21-like 2 (C. elegans) is a protein that in humans is encoded by the MAB21L2 gene.[5]

Function

This gene is similar to the C. elegans MAB-21 cell fate-determining gene, a downstream target of transforming growth factor-beta signaling. It is thought that this gene may be involved in neural development. The protein encoded by this gene is primarily nuclear, although some cytoplasmic localization has been observed. [provided by RefSeq, Jul 2008].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181541 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057777 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Mab-21-like 2 (C. elegans)".

Further reading

  • Mariani M, Baldessari D, Francisconi S, Viggiano L, Rocchi M, Zappavigna V, Malgaretti N, Consalez GG (December 1999). "Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural development". Human Molecular Genetics. 8 (13): 2397–406. doi:10.1093/hmg/8.13.2397. PMID 10556287.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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