MAPKAP1

Protein-coding gene in the species Homo sapiens
MAPKAP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3VOQ

Identifiers
AliasesMAPKAP1, JC310, MIP1, SIN1, SIN1b, SIN1g, mitogen-activated protein kinase associated protein 1, MAPK associated protein 1
External IDsOMIM: 610558; MGI: 2444554; HomoloGene: 11473; GeneCards: MAPKAP1; OMA:MAPKAP1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for MAPKAP1
Genomic location for MAPKAP1
Band9q33.3Start125,437,393 bp[1]
End125,707,234 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for MAPKAP1
Genomic location for MAPKAP1
Band2|2 BStart34,406,771 bp[2]
End34,624,950 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle of thigh

  • apex of heart

  • stromal cell of endometrium

  • oocyte

  • gastrocnemius muscle

  • secondary oocyte

  • right auricle

  • left adrenal cortex

  • left ventricle

  • right adrenal cortex
Top expressed in
  • zygote

  • genital tubercle

  • secondary oocyte

  • tail of embryo

  • spermatocyte

  • muscle of thigh

  • ventricular zone

  • interventricular septum

  • epithelium of lens

  • spermatid
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • phosphatidylinositol-3,5-bisphosphate binding
  • phosphatidylinositol-3,4-bisphosphate binding
  • phosphatidic acid binding
  • protein binding
  • phosphatidylinositol-4,5-bisphosphate binding
  • protein kinase binding
  • phosphatidylinositol-3,4,5-trisphosphate binding
Cellular component
  • Golgi apparatus
  • membrane
  • plasma membrane
  • nucleoplasm
  • cytoplasmic vesicle
  • nucleus
  • cytosol
  • TORC2 complex
  • cytoplasm
Biological process
  • substantia nigra development
  • negative regulation of Ras protein signal transduction
  • establishment or maintenance of actin cytoskeleton polarity
  • stress-activated protein kinase signaling cascade
  • TORC2 signaling
  • activation of protein kinase B activity
  • positive regulation of peptidyl-serine phosphorylation
  • regulation of cellular response to oxidative stress
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79109

227743

Ensembl

ENSG00000119487

ENSMUSG00000038696

UniProt

Q9BPZ7

Q8BKH7

RefSeq (mRNA)
NM_001006617
NM_001006618
NM_001006619
NM_001006620
NM_001006621

NM_024117

NM_001290625
NM_001290626
NM_177345
NM_001362919
NM_001362920

NM_001362921

RefSeq (protein)
NP_001006618
NP_001006619
NP_001006620
NP_001006621
NP_001006622

NP_077022

NP_001277554
NP_001277555
NP_796319
NP_001349848
NP_001349849

NP_001349850

Location (UCSC)Chr 9: 125.44 – 125.71 MbChr 2: 34.41 – 34.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene.[5][6] As the name indicates, it is a subunit of mTOR complex 2.

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119487 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038696 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schroder W, Cloonan N, Bushell G, et al. (Sep 2004). "Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene". Gene. 339: 17–23. doi:10.1016/j.gene.2004.07.001. PMID 15363842.
  6. ^ a b "Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1".

Further reading

  • Colicelli J, Nicolette C, Birchmeier C, et al. (1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2913–7. Bibcode:1991PNAS...88.2913C. doi:10.1073/pnas.88.7.2913. PMC 51350. PMID 1849280.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Schroder W, Bushell G, Sculley T (2005). "The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins". Cell. Signal. 17 (6): 761–7. doi:10.1016/j.cellsig.2004.10.015. PMID 15722200.
  • Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  • Cheng J, Zhang D, Kim K, et al. (2005). "Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation". Mol. Cell. Biol. 25 (14): 5955–64. doi:10.1128/MCB.25.14.5955-5964.2005. PMC 1168836. PMID 15988011.
  • Venables JP, Bourgeois CF, Dalgliesh C, et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon". Hum. Mol. Genet. 14 (16): 2289–303. doi:10.1093/hmg/ddi233. PMID 16000324.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Frias MA, Thoreen CC, Jaffe JD, et al. (2006). "mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s". Curr. Biol. 16 (18): 1865–70. Bibcode:2006CBio...16.1865F. doi:10.1016/j.cub.2006.08.001. PMID 16919458. S2CID 8239162.
  • Jacinto E, Facchinetti V, Liu D, et al. (2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity". Cell. 127 (1): 125–37. doi:10.1016/j.cell.2006.08.033. PMID 16962653. S2CID 230319.
  • Yang Q, Inoki K, Ikenoue T, et al. (2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes Dev. 20 (20): 2820–32. doi:10.1101/gad.1461206. PMC 1619946. PMID 17043309.
  • Makino C, Sano Y, Shinagawa T, et al. (2007). "Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway". Genes Cells. 11 (11): 1239–51. doi:10.1111/j.1365-2443.2006.01016.x. PMID 17054722. S2CID 10605647.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Schroder WA, Buck M, Cloonan N, et al. (2007). "Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling". Cell. Signal. 19 (6): 1279–89. doi:10.1016/j.cellsig.2007.01.013. PMID 17303383.


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