Protein-coding gene in the species Homo sapiens
| NUDT6 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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3FXT, 3H95 |
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| Identifiers |
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| Aliases | NUDT6, ASFGF2, FGF-AS, FGF2AS, GFG-1, GFG1, nudix hydrolase 6 |
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| External IDs | OMIM: 606261; MGI: 2387618; HomoloGene: 31425; GeneCards: NUDT6; OMA:NUDT6 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 4 (human)[1] |
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| | Band | 4q28.1 | Start | 122,888,697 bp[1] |
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| End | 122,922,968 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 3 (mouse)[2] |
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| | Band | 3|3 B | Start | 37,459,059 bp[2] |
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| End | 37,474,360 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - tendon of biceps brachii
- internal globus pallidus
- right lobe of liver
- germinal epithelium
- oocyte
- left ventricle
- right adrenal gland
- right adrenal cortex
- right ventricle
- left adrenal gland
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| | Top expressed in | - interventricular septum
- aortic valve
- ascending aorta
- right kidney
- muscle of thigh
- proximal tubule
- masseter muscle
- myocardium of ventricle
- skeletal muscle tissue
- sternocleidomastoid muscle
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - growth factor activity
- hydrolase activity
- NADH pyrophosphatase activity
- ADP-ribose diphosphatase activity
- NAD binding
| | Cellular component | - cytoplasm
- mitochondrion
- nucleus
- cellular component
| | Biological process | - regulation of signaling receptor activity
- biological process
- negative regulation of cell population proliferation
- negative regulation of cell cycle
| | Sources:Amigo / QuickGO |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene.[5][6][7]
FGF2 (MIM 134920) is a highly conserved, multifunctional heparin-binding growth factor involved in neuroectoderm development, angiogenesis, and wound healing.
Elevated levels of FGF2 are associated with proliferation of smooth muscle in atherosclerosis and with proliferation of tumors. The FGF2 antisense gene, NUDT6, may regulate FGF2 expression.[supplied by OMIM][7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000170917 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050174 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Murphy PR, Knee RS (Jan 1995). "Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene". Mol Endocrinol. 8 (7): 852–9. doi:10.1210/mend.8.7.7984147. PMID 7984147.
- ^ Gagnon ML, Moy GK, Klagsbrun M (Apr 1999). "Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells". J Cell Biochem. 72 (4): 492–506. doi:10.1002/(SICI)1097-4644(19990315)72:4<492::AID-JCB5>3.0.CO;2-H. PMID 10022609. S2CID 28384265.
- ^ a b "Entrez Gene: NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6".
Further reading
- Knee RS, Pitcher SE, Murphy PR (1995). "Basic fibroblast growth factor sense (FGF) and antisense (gfg) RNA transcripts are expressed in unfertilized human oocytes and in differentiated adult tissues". Biochem. Biophys. Res. Commun. 205 (1): 577–83. doi:10.1006/bbrc.1994.2704. PMID 7999082.
- Li AW, Too CK, Knee R, et al. (1998). "FGF-2 antisense RNA encodes a nuclear protein with MutT-like antimutator activity". Mol. Cell. Endocrinol. 133 (2): 177–82. doi:10.1016/S0303-7207(97)00148-2. PMID 9406864. S2CID 43782586.
- Asa SL, Ramyar L, Murphy PR, et al. (2001). "The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production". Mol. Endocrinol. 15 (4): 589–99. doi:10.1210/me.15.4.589. PMID 11266510.
- Duplan SM, Théorêt Y, Kenigsberg RL (2002). "Antitumor activity of fibroblast growth factors (FGFs) for medulloblastoma may correlate with FGF receptor expression and tumor variant". Clin. Cancer Res. 8 (1): 246–57. PMID 11801566.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sheng Z, Lewis JA, Chirico WJ (2004). "Nuclear and nucleolar localization of 18-kDa fibroblast growth factor-2 is controlled by C-terminal signals". J. Biol. Chem. 279 (38): 40153–60. doi:10.1074/jbc.M400123200. PMID 15247275.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Vasilescu J, Zweitzig DR, Denis NJ, et al. (2007). "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells". J. Proteome Res. 6 (1): 298–305. CiteSeerX 10.1.1.401.4220. doi:10.1021/pr060438j. PMID 17203973.
- Pezzatini S, Morbidelli L, Solito R, et al. (2007). "Nanostructured HA crystals up-regulate FGF-2 expression and activity in microvascular endothelium promoting angiogenesis". Bone. 41 (4): 523–34. doi:10.1016/j.bone.2007.06.016. PMID 17681892.
