POLR3C

Protein-coding gene in the species Homo sapiens
POLR3C
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2XUB, 2XV4, 5AFQ

Identifiers
AliasesPOLR3C, RPC3, RPC62, polymerase (RNA) III subunit C, RNA polymerase III subunit C, C82
External IDsOMIM: 617454; MGI: 1921664; HomoloGene: 38185; GeneCards: POLR3C; OMA:POLR3C - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for POLR3C
Genomic location for POLR3C
Band1q21.1Start145,824,088 bp[1]
End145,844,402 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for POLR3C
Genomic location for POLR3C
Band3|3 F2.1Start96,618,806 bp[2]
End96,634,944 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • Achilles tendon

  • stromal cell of endometrium

  • monocyte

  • left testis

  • right testis

  • canal of the cervix

  • granulocyte

  • gallbladder

  • right ovary
Top expressed in
  • otic vesicle

  • intestinal villus

  • yolk sac

  • mesenteric lymph nodes

  • granulocyte

  • epiblast

  • seminiferous tubule

  • ventricular zone

  • jejunum

  • ileum
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA-directed 5'-3' RNA polymerase activity
  • DNA binding
  • protein binding
  • RNA polymerase III activity
  • single-stranded DNA binding
Cellular component
  • RNA polymerase III complex
  • cytosol
  • nucleoplasm
  • nucleus
Biological process
  • positive regulation of interferon-beta production
  • regulation of transcription by RNA polymerase III
  • defense response to virus
  • transcription, DNA-templated
  • positive regulation of innate immune response
  • immune system process
  • innate immune response
  • transcription by RNA polymerase III
  • positive regulation of type I interferon production
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10623

74414

Ensembl

ENSG00000186141

ENSMUSG00000028099

UniProt

Q9BUI4

Q9D483

RefSeq (mRNA)

NM_001303456
NM_006468

NM_028925

RefSeq (protein)

NP_001290385
NP_006459

NP_083201

Location (UCSC)Chr 1: 145.82 – 145.84 MbChr 3: 96.62 – 96.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene.[5][6][7]


Interactions

POLR3C has been shown to interact with GTF3C4.[8][9]

Related gene problems

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186141 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028099 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang Z, Roeder RG (May 1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes & Development. 11 (10): 1315–26. doi:10.1101/gad.11.10.1315. PMID 9171375.
  6. ^ Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (November 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits" (PDF). Molecular and Cellular Biology. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
  7. ^ "Entrez Gene: POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)".
  8. ^ Hsieh YJ, Wang Z, Kovelman R, Roeder RG (July 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Molecular and Cellular Biology. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
  9. ^ Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (November 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Molecular and Cellular Biology. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
  10. ^ Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". American Journal of Human Genetics. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

Further reading

  • Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142–7. PMID 1403646.
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hsieh YJ, Wang Z, Kovelman R, Roeder RG (July 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Molecular and Cellular Biology. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
  • Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (November 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Molecular and Cellular Biology. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
  • Kuwana M, Kimura K, Kawakami Y (October 2002). "Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay". Arthritis and Rheumatism. 46 (10): 2742–7. doi:10.1002/art.10521. PMID 12384934.


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