PPIP5K2

PPIP5K2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T54, 3T7A, 3T99, 3T9A, 3T9B, 3T9C, 3T9D, 3T9E, 3T9F, 4HN2, 4NZM, 4NZN, 4NZO, 4Q4C, 4Q4D, 5BYA, 5BYB
Identifiers
Aliases	PPIP5K2, HISPPD1, IP7K2, VIP2, CFAP160, diphosphoinositol pentakisphosphate kinase 2, DFNB100
External IDs	OMIM: 611648; MGI: 2142810; HomoloGene: 49409; GeneCards: PPIP5K2; OMA:PPIP5K2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q21.1 Start 103,120,149 bp[1] End 103,212,799 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 97,706,048 bp[2] End 97,770,411 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ganglionic eminence sural nerve bone marrow cells tibia monocyte rectum ventricular zone Descending thoracic aorta left ovary Top expressed in hand superior cervical ganglion interventricular septum epithelium of small intestine secondary oocyte zygote myocardium of ventricle tail of embryo genital tubercle migratory enteric neural crest cell More reference expression data BioGPS n/a
Gene ontology Molecular function inositol hexakisphosphate 5-kinase activity transferase activity inositol hexakisphosphate 1-kinase activity nucleotide binding diphosphoinositol-pentakisphosphate kinase activity inositol-1,3,4,5,6-pentakisphosphate kinase activity inositol hexakisphosphate 3-kinase activity kinase activity inositol hexakisphosphate kinase activity ATP binding inositol heptakisphosphate kinase activity 5-diphosphoinositol pentakisphosphate 3-kinase activity Cellular component cytoplasm cytosol Biological process inositol phosphate metabolic process phosphorylation inositol phosphate biosynthetic process inositol metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23262 227399 Ensembl ENSG00000145725 ENSMUSG00000040648 UniProt O43314 Q6ZQB6 RefSeq (mRNA) NM_001276277 NM_001281471 NM_015216 NM_001345871 NM_001345872 NM_001345873 NM_001345874 NM_001345875 NM_001345876 NM_001345877 NM_001345878 NM_173760 RefSeq (protein) NP_001263206 NP_001268400 NP_001332800 NP_001332801 NP_001332802 NP_001332803 NP_001332804 NP_001332805 NP_001332806 NP_001332807 NP_056031 NP_776121 NP_001392387 NP_001392388 NP_001392389 NP_001392390 NP_001392391 NP_001392392 NP_001392393 NP_001392394 NP_001392395 NP_001392396 NP_001392397 NP_001392398 NP_001392399 NP_001392400 NP_001392401 NP_001392402 Location (UCSC) Chr 5: 103.12 – 103.21 Mb Chr 1: 97.71 – 97.77 Mb PubMed search [3] [4]
Wikidata
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Diphosphoinositol pentakisphosphate kinase 2 is a protein that in humans is encoded by the PPIP5K2 gene. ^[5]

Function

Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules.

HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.