PSME1

Protein found in humans
PSME1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1AVO

Identifiers
AliasesPSME1, IFI5111, PA28A, PA28alpha, REGalpha, HEL-S-129m, proteasome activator subunit 1
External IDsOMIM: 600654; MGI: 1096367; HomoloGene: 4560; GeneCards: PSME1; OMA:PSME1 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for PSME1
Genomic location for PSME1
Band14q12Start24,136,163 bp[1]
End24,138,967 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for PSME1
Genomic location for PSME1
Band14 C3|14 28.19 cMStart55,815,580 bp[2]
End55,818,986 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • monocyte

  • lymph node

  • spleen

  • right adrenal gland

  • duodenum

  • right adrenal cortex

  • appendix

  • left adrenal gland

  • rectum
Top expressed in
  • spleen

  • mesenteric lymph nodes

  • duodenum

  • right ventricle

  • thymus

  • right lung lobe

  • jejunum

  • blood

  • left lung

  • subcutaneous adipose tissue
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • endopeptidase activator activity
  • protein binding
Cellular component
  • proteasome complex
  • cytoplasm
  • nucleoplasm
  • proteasome activator complex
  • cytosol
  • extracellular exosome
Biological process
  • tumor necrosis factor-mediated signaling pathway
  • protein polyubiquitination
  • T cell receptor signaling pathway
  • positive regulation of canonical Wnt signaling pathway
  • anaphase-promoting complex-dependent catabolic process
  • regulation of proteasomal protein catabolic process
  • regulation of G1/S transition of mitotic cell cycle
  • regulation of mRNA stability
  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
  • antigen processing and presentation of exogenous antigen
  • regulation of cellular amino acid metabolic process
  • NIK/NF-kappaB signaling
  • Fc-epsilon receptor signaling pathway
  • negative regulation of canonical Wnt signaling pathway
  • MAPK cascade
  • stimulatory C-type lectin receptor signaling pathway
  • positive regulation of endopeptidase activity
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • Wnt signaling pathway, planar cell polarity pathway
  • negative regulation of G2/M transition of mitotic cell cycle
  • protein deubiquitination
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • transmembrane transport
  • regulation of transcription from RNA polymerase II promoter in response to hypoxia
  • post-translational protein modification
  • regulation of hematopoietic stem cell differentiation
  • interleukin-1-mediated signaling pathway
  • regulation of mitotic cell cycle phase transition
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5720

19186

Ensembl

ENSG00000092010
ENSG00000284916

ENSMUSG00000022216

UniProt

Q06323

P97371

RefSeq (mRNA)

NM_176783
NM_001281528
NM_001281529
NM_006263

NM_011189

RefSeq (protein)

NP_001268457
NP_001268458
NP_006254
NP_788955

NP_035319

Location (UCSC)Chr 14: 24.14 – 24.14 MbChr 14: 55.82 – 55.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proteasome activator complex subunit 1 is a protein that in humans is encoded by the PSME1 gene.[5][6]

Function

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.[6]

Interactions

PSME1 has been shown to interact with:

References

  1. ^ a b c ENSG00000284916 GRCh38: Ensembl release 89: ENSG00000092010, ENSG00000284916 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022216 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Honoré B, Leffers H, Madsen P, Celis JE (Feb 1994). "Interferon-gamma up-regulates a unique set of proteins in human keratinocytes. Molecular cloning and expression of the cDNA encoding the RGD-sequence-containing protein IGUP I-5111". Eur J Biochem. 218 (2): 421–30. doi:10.1111/j.1432-1033.1993.tb18392.x. PMID 8269930.
  6. ^ a b "Entrez Gene: PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)".
  7. ^ Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE (Jun 2003). "Emerin interacts in vitro with the splicing-associated factor, YT521-B". Eur. J. Biochem. 270 (11): 2459–66. doi:10.1046/j.1432-1033.2003.03617.x. PMID 12755701.
  8. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  9. ^ Ahn K, Erlander M, Leturcq D, Peterson PA, Früh K, Yang Y (Jul 1996). "In vivo characterization of the proteasome regulator PA28". J. Biol. Chem. 271 (30): 18237–42. doi:10.1074/jbc.271.30.18237. PMID 8663520.

Further reading

  • Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes". Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
  • Sijts A, Sun Y, Janek K, Kral S, Paschen A, Schadendorf D, Kloetzel PM (2002). "The role of the proteasome activator PA28 in MHC class I antigen processing". Mol. Immunol. 39 (3–4): 165–9. doi:10.1016/S0161-5890(02)00099-8. PMID 12200048.
  • Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1". Cell. 114 (3): 281–3. doi:10.1016/S0092-8674(03)00602-0. PMID 12914693.
  • Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.
  • Ahn JY, Tanahashi N, Akiyama K, Hisamatsu H, Noda C, Tanaka K, Chung CH, Shibmara N, Willy PJ, Mott JD (1995). "Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome". FEBS Lett. 366 (1): 37–42. doi:10.1016/0014-5793(95)00492-R. PMID 7789512.
  • Realini C, Dubiel W, Pratt G, Ferrell K, Rechsteiner M (1994). "Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease". J. Biol. Chem. 269 (32): 20727–32. doi:10.1016/S0021-9258(17)32052-5. PMID 8051173.
  • Ahn K, Erlander M, Leturcq D, Peterson PA, Früh K, Yang Y (1996). "In vivo characterization of the proteasome regulator PA28". J. Biol. Chem. 271 (30): 18237–42. doi:10.1074/jbc.271.30.18237. PMID 8663520.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation". J. Biol. Chem. 272 (13): 8145–8148. doi:10.1074/jbc.272.13.8145. PMID 9079628.
  • Soza A, Knuehl C, Groettrup M, Henklein P, Tanaka K, Kloetzel PM (1997). "Expression and subcellular localization of mouse 20S proteasome activator complex PA28". FEBS Lett. 413 (1): 27–34. doi:10.1016/S0014-5793(97)00864-8. PMID 9287111.
  • McCusker D, Jones T, Sheer D, Trowsdale J (1998). "Genetic relationships of the genes encoding the human proteasome beta subunits and the proteasome PA28 complex". Genomics. 45 (2): 362–7. doi:10.1006/geno.1997.4948. PMID 9344661.
  • Johnston SC, Whitby FG, Realini C, Rechsteiner M, Hill CP (1998). "The proteasome 11S regulator subunit REG alpha (PA28 alpha) is a heptamer". Protein Sci. 6 (11): 2469–73. doi:10.1002/pro.5560061123. PMC 2143584. PMID 9385652.
  • Wang X, Omura S, Szweda LI, Yang Y, Bérard J, Seminaro J, Wu J (1998). "Rapamycin inhibits proteasome activator expression and proteasome activity". Eur. J. Immunol. 27 (11): 2781–6. doi:10.1002/eji.1830271106. PMID 9394799. S2CID 23525256.
  • Knowlton JR, Johnston SC, Whitby FG, Realini C, Zhang Z, Rechsteiner M, Hill CP (1998). "Structure of the proteasome activator REGalpha (PA28alpha)". Nature. 390 (6660): 639–43. Bibcode:1997Natur.390..639K. doi:10.1038/37670. PMID 9403698. S2CID 4309279.
  • Kohda K, Ishibashi T, Shimbara N, Tanaka K, Matsuda Y, Kasahara M (1998). "Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes". J. Immunol. 160 (10): 4923–35. doi:10.4049/jimmunol.160.10.4923. PMID 9590240.
  • Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein". J. Virol. 72 (12): 10251–5. doi:10.1128/JVI.72.12.10251-10255.1998. PMC 110608. PMID 9811770.
  • Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". Nat. Med. 4 (12): 1397–400. doi:10.1038/3987. PMID 9846577. S2CID 25235070.
  • McCusker D, Wilson M, Trowsdale J (1999). "Organization of the genes encoding the human proteasome activators PA28alpha and beta". Immunogenetics. 49 (5): 438–45. doi:10.1007/s002510050517. PMID 10199920. S2CID 40575791.
  • v
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  • 1avo: PROTEASOME ACTIVATOR REG(ALPHA)
    1avo: PROTEASOME ACTIVATOR REG(ALPHA)
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A (alpha subunits)
B (beta subunits)
C (ATPases)
D (non-ATPases)
E (activator subunits)
F (inhibitor subunit)
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