RCC2

Protein-coding gene in the species Homo sapiens
RCC2
Identifiers
AliasesRCC2, TD-60, regulator of chromosome condensation 2
External IDsOMIM: 609587; MGI: 1919784; HomoloGene: 10282; GeneCards: RCC2; OMA:RCC2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RCC2
Genomic location for RCC2
Band1p36.13Start17,406,760 bp[1]
End17,439,677 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for RCC2
Genomic location for RCC2
Band4|4 D3Start140,427,852 bp[2]
End140,450,531 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • lymph node

  • monocyte

  • skin of abdomen

  • stromal cell of endometrium

  • ventricular zone

  • skin of leg

  • appendix

  • granulocyte

  • gonad
Top expressed in
  • ventricular zone

  • primitive streak

  • somite

  • epiblast

  • thymus

  • abdominal wall

  • fetal liver hematopoietic progenitor cell

  • ganglionic eminence

  • medial ganglionic eminence

  • lip
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein domain specific binding
  • microtubule binding
  • small GTPase binding
  • protein binding
  • protein kinase binding
  • RNA binding
  • guanyl-nucleotide exchange factor activity
Cellular component
  • cytoplasm
  • cytosol
  • early endosome membrane
  • membrane
  • plasma membrane
  • spindle
  • chromosome, centromeric core domain
  • chromosome
  • mitotic spindle midzone
  • midbody
  • nucleolus
  • microtubule
  • chromosome, centromeric region
  • cytoskeleton
  • nucleus
Biological process
  • regulation of cell migration
  • activation of GTPase activity
  • establishment of protein localization
  • cell division
  • chromosome passenger complex localization to kinetochore
  • positive regulation of attachment of spindle microtubules to kinetochore
  • focal adhesion assembly
  • negative regulation of GTPase activity
  • regulation of ruffle assembly
  • integrin-mediated signaling pathway
  • positive regulation of G2/M transition of mitotic cell cycle
  • cell cycle
  • negative regulation of substrate adhesion-dependent cell spreading
  • regulation of fibroblast migration
  • negative regulation of focal adhesion assembly
  • sister chromatid cohesion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55920

108911

Ensembl

ENSG00000281540
ENSG00000179051

ENSMUSG00000040945

UniProt

Q9P258

Q8BK67

RefSeq (mRNA)

NM_018715
NM_001136204

NM_173867

RefSeq (protein)

NP_001129676
NP_061185
NP_001129676.1
NP_061185.1

NP_776292

Location (UCSC)Chr 1: 17.41 – 17.44 MbChr 4: 140.43 – 140.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein RCC2 also known as telophase disk protein of 60 kDa (TD-60) or RCC1-like protein TD-60 is a protein that in humans is encoded by the RCC2 gene.[5][6][7]

Function

RCC2 has structural similarity to RCC1, and has been shown to have weak guanine nucleotide exchange factor (GEF) activity on the small GTPase Rac.[6] TD-60 has also been shown to interact with the Chromosomal Passenger Complex (CPC), and to activate the catalytic component of the CPC, Aurora B, in the presence of microtubules.[8][9]

References

  1. ^ a b c ENSG00000179051 GRCh38: Ensembl release 89: ENSG00000281540, ENSG00000179051 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040945 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  6. ^ a b Mollinari C, Reynaud C, Martineau-Thuillier S, Monier S, Kieffer S, Garin J, Andreassen PR, Boulet A, Goud B, Kleman JP, Margolis RL (Aug 2003). "The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression". Dev Cell. 5 (2): 295–307. doi:10.1016/S1534-5807(03)00205-3. PMID 12919680.
  7. ^ "Entrez Gene: RCC2 regulator of chromosome condensation 2".
  8. ^ Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (July 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.
  9. ^ Rosasco-Nitcher SE, Lan W, Khorasanizadeh S, Stukenberg PT (January 2008). "Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation". Science. 319 (5862): 469–72. Bibcode:2008Sci...319..469R. doi:10.1126/science.1148980. PMID 18218899. S2CID 10374348.

Further reading

  • Andreassen PR, Palmer DK, Wener MH, Margolis RL (1991). "Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis". J. Cell Sci. 99 (3): 523–34. doi:10.1242/jcs.99.3.523. PMID 1939370.
  • Martineau SN, Andreassen PR, Margolis RL (1995). "Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery". J. Cell Biol. 131 (1): 191–205. doi:10.1083/jcb.131.1.191. PMC 2120587. PMID 7559776.
  • Martineau-Thuillier S, Andreassen PR, Margolis RL (1999). "Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis". Chromosoma. 107 (6–7): 461–70. doi:10.1007/s004120050330. PMID 9914378. S2CID 24935187.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gassmann R, Carvalho A, Henzing AJ, et al. (2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Rosasco-Nitcher, Sara; Lan W; Khorasanizadeh S; Stukenberg PT. (January 2008). "Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation". Science. 319 (5862): 469–472. Bibcode:2008Sci...319..469R. doi:10.1126/science.1148980. PMID 18218899. S2CID 10374348.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q9P258 (Protein RCC2) at the PDBe-KB.
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