SNRPA1

Protein-coding gene in the species Homo sapiens
SNRPA1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1A9N

Identifiers
AliasesSNRPA1, Lea1, small nuclear ribonucleoprotein polypeptide A', U2A'
External IDsOMIM: 603521; MGI: 1916231; HomoloGene: 2325; GeneCards: SNRPA1; OMA:SNRPA1 - orthologs
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[1]
Chromosome 7 (mouse)
Genomic location for SNRPA1
Genomic location for SNRPA1
Band7|7 CStart65,708,751 bp[1]
End65,724,335 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • lymph node

  • thymus

  • bone marrow

  • spleen

  • monocyte

  • appendix

  • tibial nerve

  • right lung

  • rectum
Top expressed in
  • primitive streak

  • Paneth cell

  • condyle

  • fossa

  • abdominal wall

  • superior cervical ganglion

  • motor neuron

  • medullary collecting duct

  • ureter

  • vas deferens
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • U2 snRNA binding
  • protein binding
  • RNA binding
Cellular component
  • catalytic step 2 spliceosome
  • spliceosomal complex
  • small nuclear ribonucleoprotein complex
  • nucleus
  • U2 snRNP
  • nucleoplasm
  • nuclear speck
  • nuclear body
  • U2-type precatalytic spliceosome
  • U2-type catalytic step 2 spliceosome
  • viral nucleocapsid
Biological process
  • mRNA splicing, via spliceosome
  • mRNA processing
  • RNA splicing
  • interleukin-12-mediated signaling pathway
  • spermatogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6627

68981

Ensembl

n/a

ENSMUSG00000030512

UniProt

P09661

P57784

RefSeq (mRNA)

NM_003090

NM_021336

RefSeq (protein)

NP_003081

NP_067311

Location (UCSC)n/aChr 7: 65.71 – 65.72 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the SNRPA1 gene.[4][5]

Interactions

SNRPA1 has been shown to interact with CDC5L.[6]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030512 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Sillekens PT, Beijer RP, Habets WJ, van Verooij WJ (March 1989). "Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein". Nucleic Acids Research. 17 (5): 1893–906. doi:10.1093/nar/17.5.1893. PMC 317531. PMID 2928112.
  5. ^ "Entrez Gene: SNRPA1 small nuclear ribonucleoprotein polypeptide A'".
  6. ^ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

Further reading

  • Ohno M, Kataoka N, Shimura Y (December 1990). "A nuclear cap binding protein from HeLa cells". Nucleic Acids Research. 18 (23): 6989–95. doi:10.1093/nar/18.23.6989. PMC 332760. PMID 2148205.
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Kjems J, Sharp PA (August 1993). "The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly". Journal of Virology. 67 (8): 4769–76. doi:10.1128/JVI.67.8.4769-4776.1993. PMC 237863. PMID 8331728.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Blencowe BJ, Issner R, Nickerson JA, Sharp PA (April 1998). "A coactivator of pre-mRNA splicing". Genes & Development. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
  • Price SR, Evans PR, Nagai K (August 1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA". Nature. 394 (6694): 645–50. Bibcode:1998Natur.394..645P. doi:10.1038/29234. PMID 9716128. S2CID 204999419.
  • Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, et al. (September 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nature Genetics. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.
  • Eldridge AG, Li Y, Sharp PA, Blencowe BJ (May 1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proceedings of the National Academy of Sciences of the United States of America. 96 (11): 6125–30. Bibcode:1999PNAS...96.6125E. doi:10.1073/pnas.96.11.6125. PMC 26846. PMID 10339552.
  • Lundin M, Mikkelsen B, Gudim M, Syed M (March 2000). "Gene Structure of the U2 snRNP-Specific A' Protein Gene from Salmo salar: Alternative Transcripts Observed". Marine Biotechnology. 2 (2): 204–211. doi:10.1007/s101269900015. PMID 10811961. S2CID 20060370.
  • Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068. S2CID 1518837.
  • Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, et al. (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
  • Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (April 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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  • 1a9n: CRYSTAL STRUCTURE OF THE SPLICEOSOMAL U2B''-U2A' PROTEIN COMPLEX BOUND TO A FRAGMENT OF U2 SMALL NUCLEAR RNA
    1a9n: CRYSTAL STRUCTURE OF THE SPLICEOSOMAL U2B''-U2A' PROTEIN COMPLEX BOUND TO A FRAGMENT OF U2 SMALL NUCLEAR RNA
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