SYCP1

Protein-coding gene in the species Homo sapiens
SYCP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4YTO

Identifiers
AliasesSYCP1, CT8, HOM-TES-14, SCP-1, SCP1, synaptonemal complex protein 1
External IDsOMIM: 602162; MGI: 105931; HomoloGene: 2389; GeneCards: SYCP1; OMA:SYCP1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SYCP1
Genomic location for SYCP1
Band1p13.2Start114,854,863 bp[1]
End114,995,370 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for SYCP1
Genomic location for SYCP1
Band3|3 F2.2Start102,725,815 bp[2]
End102,843,416 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • right testis

  • left testis

  • buccal mucosa cell

  • testicle

  • gonad

  • granulocyte

  • tibialis anterior muscle

  • ventricular zone

  • mononuclear cell
Top expressed in
  • spermatocyte

  • spermatid

  • seminiferous tubule

  • morula

  • zygote

  • secondary oocyte

  • uterine tube

  • embryo

  • primary oocyte

  • embryo
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • double-stranded DNA binding
Cellular component
  • condensed nuclear chromosome
  • central element
  • male germ cell nucleus
  • chromosome
  • transverse filament
  • nucleus
  • synaptonemal complex
  • chromosome, centromeric region
Biological process
  • lateral element assembly
  • spermatogenesis
  • meiosis
  • sperm DNA condensation
  • regulation of protein localization
  • meiotic DNA repair synthesis
  • chiasma assembly
  • cell division
  • cell cycle
  • synaptonemal complex assembly
  • homologous chromosome pairing at meiosis
  • reciprocal meiotic recombination
  • protein homotetramerization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6847

20957

Ensembl

ENSG00000198765

ENSMUSG00000027855

UniProt

Q15431

Q62209

RefSeq (mRNA)

NM_001282541
NM_001282542
NM_003176

NM_011516

RefSeq (protein)

NP_001269470
NP_001269471
NP_003167
NP_001269470.1
NP_003167.2

NP_035646

Location (UCSC)Chr 1: 114.85 – 115 MbChr 3: 102.73 – 102.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptonemal complex protein 1 is a protein involved in the synaptonemal complex during meiosis, that in humans is encoded by the SYCP1 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198765 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027855 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tureci O, Sahin U, Zwick C, Koslowski M, Seitz G, Pfreundschuh M (Jun 1998). "Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens". Proc Natl Acad Sci U S A. 95 (9): 5211–6. Bibcode:1998PNAS...95.5211T. doi:10.1073/pnas.95.9.5211. PMC 20240. PMID 9560255.
  6. ^ "Entrez Gene: SYCP1 synaptonemal complex protein 1".

Further reading

  • Neumann F, Wagner C, Preuss KD, et al. (2005). "Identification of an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4+ T cells". Blood. 106 (9): 3105–13. doi:10.1182/blood-2005-04-1487. PMID 16030183.
  • Costa Y, Speed R, Ollinger R, et al. (2005). "Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis". J. Cell Sci. 118 (Pt 12): 2755–62. doi:10.1242/jcs.02402. PMID 15944401.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
  • Kondoh N, Nishina Y, Tsuchida J, et al. (1997). "Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis". Cytogenet. Cell Genet. 78 (2): 103–4. doi:10.1159/000134637. PMID 9371398.
  • Meuwissen RL, Meerts I, Hoovers JM, et al. (1997). "Human synaptonemal complex protein 1 (SCP1): isolation and characterization of the cDNA and chromosomal localization of the gene" (PDF). Genomics. 39 (3): 377–84. doi:10.1006/geno.1996.4373. PMID 9119375. S2CID 260928260.
  • Meuwissen RL, Offenberg HH, Dietrich AJ, et al. (1993). "A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes". EMBO J. 11 (13): 5091–100. doi:10.1002/j.1460-2075.1992.tb05616.x. PMC 556987. PMID 1464329.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q62209 (Synaptonemal complex protein 1) at the PDBe-KB.
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