TNFAIP8

Protein-coding gene in the species Homo sapiens
TNFAIP8
Identifiers
AliasesTNFAIP8, GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2, TNF alpha induced protein 8
External IDsOMIM: 612111; MGI: 2147191; HomoloGene: 8649; GeneCards: TNFAIP8; OMA:TNFAIP8 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for TNFAIP8
Genomic location for TNFAIP8
Band5q23.1Start119,268,692 bp[1]
End119,399,688 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for TNFAIP8
Genomic location for TNFAIP8
Band18|18 D1Start50,112,494 bp[2]
End50,240,240 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cartilage tissue

  • epithelium of nasopharynx

  • appendix

  • bone marrow

  • white blood cell

  • mononuclear cell

  • monocyte

  • lymph node

  • bone marrow cells

  • trabecular bone
Top expressed in
  • gastrula

  • right kidney

  • granulocyte

  • decidua

  • thymus

  • human kidney

  • primary oocyte

  • spleen

  • conjunctival fornix

  • myocardium of ventricle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process
  • protein binding
Cellular component
  • cytoplasm
  • nucleoplasm
Biological process
  • negative regulation of apoptotic process
  • apoptotic process
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • positive regulation of apoptotic process
  • regulation of apoptotic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25816

106869

Ensembl

ENSG00000145779

ENSMUSG00000062210

UniProt

O95379

Q921Z5

RefSeq (mRNA)
NM_014350
NM_001077654
NM_001286813
NM_001286814
NM_001286815

NM_001286817

NM_001177759
NM_001177760
NM_134131
NM_001360935

RefSeq (protein)
NP_001071122
NP_001273742
NP_001273743
NP_001273744
NP_001273746

NP_055165

NP_001171230
NP_001171231
NP_598892
NP_001347864

Location (UCSC)Chr 5: 119.27 – 119.4 MbChr 18: 50.11 – 50.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tumor necrosis factor, alpha-induced protein 8 is a protein that in humans is encoded by the TNFAIP8 gene.[5][6][7] It is preferentially expressed in human immune cell types.[8]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145779 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062210 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H (Jun 1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood. 93 (10): 3418–31. doi:10.1182/blood.V93.10.3418.410k23_3418_3431. PMID 10233894.
  6. ^ Kumar D, Whiteside TL, Kasid U (Feb 2000). "Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin- 1beta-converting enzyme-inhibitory protein". J Biol Chem. 275 (4): 2973–8. doi:10.1074/jbc.275.4.2973. PMID 10644768.
  7. ^ "Entrez Gene: TNFAIP8 tumor necrosis factor, alpha-induced protein 8".
  8. ^ Li T, Wang W, et al. (May 2018). "Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism". Molecular Immunology. 99: 154–162. doi:10.1016/j.molimm.2018.05.007. PMC 5995464. PMID 29787979.

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Kumar D, Gokhale P, Broustas C, et al. (2004). "Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells". Oncogene. 23 (2): 612–6. doi:10.1038/sj.onc.1207123. PMID 14724590.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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