VAV3

Protein-coding gene in the species Homo sapiens

VAV3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2D86

Identifiers

Aliases

VAV3, vav guanine nucleotide exchange factor 3

External IDs

OMIM: 605541; MGI: 1888518; HomoloGene: 38143; GeneCards: VAV3; OMA:VAV3 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p13.3	Start	107,571,161 bp^[1]
Band	1p13.3	End	107,965,180 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 F3	Start	109,247,969 bp^[2]
Band	3\|3 F3	End	109,593,014 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

renal medulla

skin of thigh

gingival epithelium

skin of hip

secondary oocyte

kidney tubule

tibia

rectum

palpebral conjunctiva

hair follicle

Top expressed in

habenula

hair follicle

medullary collecting duct

medial dorsal nucleus

granulocyte

medial geniculate nucleus

spermatid

conjunctival fornix

Paneth cell

lateral geniculate nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding metal ion binding epidermal growth factor receptor binding GTPase activator activity guanyl-nucleotide exchange factor activity
Cellular component	cytoplasm cytosol plasma membrane
Biological process	angiogenesis Fc-gamma receptor signaling pathway involved in phagocytosis intracellular signal transduction ephrin receptor signaling pathway lamellipodium assembly regulation of Rho protein signal transduction positive regulation of phosphatidylinositol 3-kinase activity vascular endothelial growth factor receptor signaling pathway small GTPase mediated signal transduction B cell receptor signaling pathway cell projection assembly Fc-epsilon receptor signaling pathway positive regulation of apoptotic process integrin-mediated signaling pathway cellular response to DNA damage stimulus regulation of cell size regulation of small GTPase mediated signal transduction cell migration platelet activation vesicle fusion positive regulation of cell adhesion positive regulation of B cell proliferation neutrophil chemotaxis regulation of GTPase activity positive regulation of signal transduction positive regulation of GTPase activity G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10451


57257

Ensembl


ENSG00000134215


ENSMUSG00000033721

UniProt


Q9UKW4


Q9R0C8

RefSeq (mRNA)


NM_001079874 NM_006113


NM_020505 NM_146139 NM_001378987

RefSeq (protein)


NP_001073343 NP_006104


NP_065251 NP_666251 NP_001365916

Location (UCSC)

Chr 1: 107.57 – 107.97 Mb

Chr 3: 109.25 – 109.59 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.^[5]

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[5]

Interactions

VAV3 has been shown to interact with Grb2.^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134215 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033721 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: VAV3 vav 3 oncogene".
^ Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–318. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067. S2CID 26838266.
^ Zeng, L; Sachdev P; Yan L; Chan J L; Trenkle T; McClelland M; Welsh J; Wang L H (December 2000). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. 20 (24): 9212–9224. doi:10.1128/MCB.20.24.9212-9224.2000. ISSN 0270-7306. PMC 102179. PMID 11094073.

Hobert O, Schilling JW, Beckerle MC, et al. (1996). "SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin". Oncogene. 12 (7): 1577–81. PMID 8622875.
Tamma SM, Chirmule N, Yagura H, et al. (1997). "CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells". Blood. 90 (4): 1588–93. doi:10.1182/blood.V90.4.1588. PMID 9269777.
Trenkle T, Welsh J, Jung B, et al. (1998). "Non-stoichiometric reduced complexity probes for cDNA arrays". Nucleic Acids Res. 26 (17): 3883–3891. doi:10.1093/nar/26.17.3883. PMC 147802. PMID 9705494.
Movilla N, Bustelo XR (1999). "Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins". Mol. Cell. Biol. 19 (11): 7870–85. doi:10.1128/mcb.19.11.7870. PMC 84867. PMID 10523675.
Trenkle T, McClelland M, Adlkofer K, Welsh J (2000). "Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors". Gene. 245 (1): 139–149. doi:10.1016/S0378-1119(00)00026-3. PMID 10713454.
Zeng L, Sachdev P, Yan L, et al. (2001). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. 20 (24): 9212–9224. doi:10.1128/MCB.20.24.9212-9224.2000. PMC 102179. PMID 11094073.
Inabe K, Ishiai M, Scharenberg AM, et al. (2002). "Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation". J. Exp. Med. 195 (2): 189–200. doi:10.1084/jem.20011571. PMC 2193613. PMID 11805146.
Yabana N, Shibuya M (2002). "Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity". Oncogene. 21 (50): 7720–7729. doi:10.1038/sj.onc.1205927. PMID 12400014.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Zakaria S, Gomez TS, Savoy DN, et al. (2004). "Differential regulation of TCR-mediated gene transcription by Vav family members". J. Exp. Med. 199 (3): 429–434. doi:10.1084/jem.20031228. PMC 2211790. PMID 14757747.
Pearce AC, Senis YA, Billadeau DD, et al. (2005). "Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen". J. Biol. Chem. 279 (52): 53955–53962. doi:10.1074/jbc.M410355200. PMID 15456756.
Charvet C, Canonigo AJ, Billadeau DD, Altman A (2005). "Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76". J. Biol. Chem. 280 (15): 15289–15299. doi:10.1074/jbc.M500275200. PMID 15708849.
Lyons LS, Burnstein KL (2006). "Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity". Mol. Endocrinol. 20 (5): 1061–1072. doi:10.1210/me.2005-0346. PMID 16384856. S2CID 43049417.
Dong Z, Liu Y, Lu S, et al. (2006). "Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer". Mol. Endocrinol. 20 (10): 2315–2325. doi:10.1210/me.2006-0048. PMID 16762975.