ZBED6

Protein-coding gene in the species Homo sapiens
ZBED6
Identifiers
AliasesZBED6, MGR, zinc finger BED-type containing 6
External IDsOMIM: 613512; MGI: 3828086; HomoloGene: 130066; GeneCards: ZBED6; OMA:ZBED6 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ZBED6
Genomic location for ZBED6
Band1q32.1Start203,795,714 bp[1]
End203,854,999 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for ZBED6
Genomic location for ZBED6
Band1|1 E4Start133,547,678 bp[2]
End133,589,056 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bone marrow cells

  • gonad

  • epithelium of colon

  • tonsil

  • islet of Langerhans

  • stromal cell of endometrium

  • Achilles tendon

  • duodenum

  • smooth muscle tissue

  • sural nerve
Top expressed in
  • ascending aorta

  • aortic valve

  • tail of embryo

  • olfactory tubercle

  • genital tubercle

  • arcuate nucleus

  • median eminence

  • medial geniculate nucleus

  • inferior colliculus

  • paraventricular nucleus of hypothalamus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • protein dimerization activity
  • metal ion binding
  • DNA-binding transcription factor activity
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleolus
  • nucleus
Biological process
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

100381270

667118

Ensembl

ENSG00000257315

ENSMUSG00000094410

UniProt

P86452

D2EAC2

RefSeq (mRNA)

NM_001174108
NM_001395895

NM_001166552
NM_001395904

RefSeq (protein)

NP_001167579

NP_001160024
NP_001382833

Location (UCSC)Chr 1: 203.8 – 203.85 MbChr 1: 133.55 – 133.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger, BED-type containing 6 is a protein that in humans is encoded by the ZBED6 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000257315 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000094410 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Zinc finger, BED-type containing 6". Retrieved 2012-03-15.

Further reading

  • Markljung E, Jiang L, Jaffe JD, Mikkelsen TS, Wallerman O, Larhammar M, Zhang X, Wang L, Saenz-Vash V, Gnirke A, Lindroth AM, Barrés R, Yan J, Strömberg S, De S, Pontén F, Lander ES, Carr SA, Zierath JR, Kullander K, Wadelius C, Lindblad-Toh K, Andersson G, Hjälm G, Andersson L (Dec 2009). O'Rahilly S (ed.). "ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth". PLOS Biology. 7 (12): e1000256. doi:10.1371/journal.pbio.1000256. PMC 2780926. PMID 20016685.
  • Butter F, Kappei D, Buchholz F, Vermeulen M, Mann M (Apr 2010). "A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth". EMBO Reports. 11 (4): 305–11. doi:10.1038/embor.2010.6. PMC 2854606. PMID 20134481.
  • Andersson L (2010). "Studying phenotypic evolution in domestic animals: a walk in the footsteps of Charles Darwin". Cold Spring Harbor Symposia on Quantitative Biology. 74: 319–25. doi:10.1101/sqb.2009.74.039. PMID 20375320.


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