ZC3H11A

Protein-coding gene in the species Homo sapiens
ZC3H11A
Identifiers
AliasesZC3H11A, ZC3HDC11A, zinc finger CCCH-type containing 11A
External IDsOMIM: 613513; MGI: 1917829; HomoloGene: 8888; GeneCards: ZC3H11A; OMA:ZC3H11A - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ZC3H11A
Genomic location for ZC3H11A
Band1q32.1Start203,795,654 bp[1]
End203,854,999 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus callosum

  • endometrium

  • lymph node

  • cerebellar hemisphere

  • Achilles tendon

  • right hemisphere of cerebellum

  • ventricular zone

  • skin of abdomen

  • pituitary gland

  • skin of leg
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • RNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • mRNA binding
Cellular component
  • transcription export complex
  • nucleoplasm
Biological process
  • poly(A)+ mRNA export from nucleus
  • mRNA transport
  • RNA export from nucleus
  • termination of RNA polymerase II transcription
  • mRNA 3'-end processing
  • mRNA export from nucleus
  • transport
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9877

70579

Ensembl

ENSG00000058673

ENSMUSG00000102976
ENSMUSG00000116275

UniProt

O75152

Q6NZF1

RefSeq (mRNA)
NM_014827
NM_001319238
NM_001319239
NM_001350261
NM_001350262

NM_001350263
NM_001350264
NM_001350265
NM_001350266

NM_001276767
NM_144530
NM_001357228

RefSeq (protein)
NP_001306167
NP_001306168
NP_055642
NP_001337190
NP_001337191

NP_001337192
NP_001337193
NP_001337194
NP_001337195
NP_001363263
NP_001363264
NP_001363265
NP_001363266
NP_001363267
NP_001363268
NP_001363269
NP_001363270
NP_001363271
NP_001363272
NP_001363273
NP_001363274
NP_001363275
NP_001363276
NP_001363277
NP_001363278
NP_001363279
NP_001363280
NP_001363281
NP_001363282
NP_001363283
NP_001363284
NP_001363285
NP_001363286
NP_001363287
NP_001363288
NP_001363289
NP_001363290
NP_001363291
NP_001363292
NP_001363293
NP_001363294
NP_001363295
NP_001363296

NP_001263696
NP_653113
NP_001344157

Location (UCSC)Chr 1: 203.8 – 203.85 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger CCCH domain-containing protein 11A is a protein that in humans is encoded by the ZC3H11A gene.[4][5] ZC3H11A is a part of the transcription export (TREX) complex and plays a role in exporting of mRNAs from nucleus to cytoplasm.[6] It is considered as stress-induced nuclear protein and maintains mRNAs exporting when the cells are under stress.[7] Loss of functioning of ZC3H11A gene in HeLa cells results in abortion of the replication of nuclear replicating viruses but not cytoplasmic replicating viruses.[8] It is discovered that ZC3H11A is significant for viability and metabolic regulation of mouse embryo[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000058673 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, et al. (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–176. doi:10.1093/dnares/5.3.169. PMID 9734811.
  5. ^ "Entrez Gene: ZC3H11A zinc finger CCCH-type containing 11A".
  6. ^ Folco EG, Lee CS, Dufu K, Yamazaki T, Reed R (23 August 2012). "The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export". PLOS ONE. 7 (8): e43804. Bibcode:2012PLoSO...743804F. doi:10.1371/journal.pone.0043804. PMC 3426524. PMID 22928037.
  7. ^ Younis S, Kamel W, Falkeborn T, Wang H, Yu D, Daniels R, et al. (April 2018). "Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth". Proceedings of the National Academy of Sciences of the United States of America. 115 (16): E3808–E3816. Bibcode:2018PNAS..115E3808Y. doi:10.1073/pnas.1722333115. PMC 5910864. PMID 29610341.
  8. ^ Younis S, Kamel W, Falkeborn T, Wang H, Yu D, Daniels R, et al. (April 2018). "Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth". Proceedings of the National Academy of Sciences of the United States of America. 115 (16): E3808–E3816. Bibcode:2018PNAS..115E3808Y. doi:10.1073/pnas.1722333115. PMC 5910864. PMID 29610341.
  9. ^ Younis S, Jouneau A, Larsson M, Oudin JF, Adenot P, Omar J, et al. (June 2023). "Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes". Proceedings of the National Academy of Sciences of the United States of America. 120 (23): e2216799120. Bibcode:2023PNAS..12016799Y. doi:10.1073/pnas.2216799120. PMC 10266022. PMID 37252988.

Further reading

  • Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, et al. (February 2001). "The sequence of the human genome". Science. 291 (5507): 1304–1351. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
  • Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–5396. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
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