Zavegepant

Medication for treatment of migraine

  • US DailyMed: Zavegepant
Routes of
administrationNasalDrug classCalcitonin gene-related peptide receptor antagonistATC code
  • None
Legal statusLegal status
  • US: ℞-only[1]
Identifiers
  • N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl]-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide
CAS Number
  • 1337918-83-8
  • as HCl: 1414976-20-7
PubChem CID
  • 53472683
  • as HCl: 134819878
DrugBank
  • DB15688
ChemSpider
  • 30814207
UNII
  • ODU3ZAZ94J
  • as HCl: 000QCM6HAL
KEGG
  • D11898
  • as HCl: D11899
ChEBI
  • CHEBI:229643
ChEMBL
  • ChEMBL2397415
  • as HCl: ChEMBL4650220
CompTox Dashboard (EPA)
  • DTXSID101352039 Edit this at Wikidata
Chemical and physical dataFormulaC36H46N8O3Molar mass638.817 g·mol−13D model (JSmol)
  • Interactive image
  • CC1=CC(=CC2=C1NN=C2)CC(C(=O)N3CCN(CC3)C4CCN(CC4)C)NC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O
  • InChI=1S/C36H46N8O3/c1-24-19-25(20-28-23-37-40-33(24)28)21-32(35(46)43-17-15-42(16-18-43)29-9-11-41(2)12-10-29)39-36(47)44-13-7-26(8-14-44)30-22-27-5-3-4-6-31(27)38-34(30)45/h3-6,19-20,22-23,26,29,32H,7-18,21H2,1-2H3,(H,37,40)(H,38,45)(H,39,47)/t32-/m1/s1
  • Key:JJVAPHYEOZSKJZ-JGCGQSQUSA-N
  • Key:VQDUWCSSPSOSNA-RYWNGCACSA-N

Zavegepant, sold under the brand name Zavzpret, is a medication used for the treatment of migraine.[1] Zavegepant is a calcitonin gene-related peptide receptor antagonist.[1] It is sprayed into the nose.[1] It is sold by Pfizer.[1]

The most common adverse reactions include taste disorders, nausea, nasal discomfort, and vomiting.[1]

Zavegepant was approved for medical use in the United States in March 2023.[1][2][3][4]

Medical uses

Zavegepant is indicated for the acute treatment of migraine with or without aura in adults.[1][5][6]

References

  1. ^ a b c d e f g h "Zavzpret- zavegepant spray". DailyMed. 9 March 2023. Retrieved 25 August 2023.
  2. ^ "Drug Approval Package: Zavzpret". U.S. Food and Drug Administration (FDA). 3 April 2023. Retrieved 25 August 2023.
  3. ^ "Pfizer's Zavzpret (Zavegepant) Migraine Nasal Spray Receives FDA Approval" (Press release). 10 March 2023.
  4. ^ Dhillon S (June 2023). "Zavegepant: First Approval". Drugs. 83 (9): 825–831. doi:10.1007/s40265-023-01885-6. PMC 10209931. PMID 37227596.
  5. ^ Khan ZZ, Ahmed U, Shahzad F, Ali M, Tousif K, Ahmed U, et al. (July 2023). "Safety and Efficacy of Zavegepant in Treating Migraine: A Systematic Review". Cureus. 15 (7): e41991. doi:10.7759/cureus.41991. PMC 10428082. PMID 37593294.
  6. ^ Martirosov AL, Giuliano C, Shupp M, Channey S, Kale-Pradhan PB (October 2023). "Zavegepant Intranasal Spray for Migraines". The Annals of Pharmacotherapy: 10600280231209439. doi:10.1177/10600280231209439. PMID 37897226. S2CID 264543368.

Further reading

  • Croop R, Madonia J, Stock DA, Thiry A, Forshaw M, Murphy A, Coric V, Lipton RB (October 2022). "Zavegepant nasal spray for the acute treatment of migraine: A Phase 2/3 double-blind, randomized, placebo-controlled, dose-ranging trial". Headache. 62 (9): 1153–1163. doi:10.1111/head.14389. PMC 9827820. PMID 36239038.
  • Noor N, Angelette A, Lawson A, Patel A, Urits I, Viswanath O, et al. (2022). "A Comprehensive Review of Zavegepant as Abortive Treatment for Migraine". Health Psychology Research. 10 (3): 35506. doi:10.52965/001c.35506. PMC 9239361. PMID 35774914.
  • Scuteri D, Tarsitano A, Tonin P, Bagetta G, Corasaniti MT (November 2022). "Focus on zavegepant: the first intranasal third-generation gepant". Pain Management. 12 (8): 879–885. doi:10.2217/pmt-2022-0054. PMID 36189708. S2CID 252681912.

External links

  • Clinical trial number NCT04571060 for "Randomized Trial in Adult Subjects With Acute Migraines" at ClinicalTrials.gov
  • Clinical trial number NCT03872453 for "Acute Treatment Trial in Adult Subjects With Migraines" at ClinicalTrials.gov
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