Étienne-Émile Baulieu
Etienne-Emile Baulieu (ur. 12 grudnia 1926 w Strasburgu) – francuski lekarz żydowskiego pochodzenia, biochemik i endokrynolog. Emerytowany profesor nauk medycznych.
Życiorys
Był dyrektorem Research Unit w INSERM, oraz profesorem biochemii na Wydziale Medycyny Bicêtro Uniwersytetu Paryskiego. W latach 2003 i 2004 sprawował funkcję prezydenta we Francuskiej Akademii Nauk. Zajmuje się badaniami nad hormonami steroidowymi i ich funkcją w procesie starzenia się organizmu, rozrodczości i procesach nowotworowych. Odkrywca produkowanego przez nadnercza hormonu DHEA i jego roli w procesie starzenia się mózgu. Wynalazł wczesnoporonną pigułkę RU-486. Laureat wielu międzynarodowych nagród i wyróżnień, m.in.:
- doctor honoris causa Tufts University w Bostonie;
- doctor honoris causa University of Gandawa;
- doctor honoris causa Karolinska Institutet w Sztokholmie.
Kawaler Legii Honorowej.
Najważniejsze publikacje naukowe
- E.E.E.E. Baulieu E.E.E.E., I.I. Lasnizki I.I., P.P. Robel P.P., Metabolism of testosterone and action of metabolites on prostate glands grown in organ culture, „Nature”, 219 (5159), 1968, s. 1155–1156, DOI: 10.1038/2191155a0, PMID: 5675630 .
- E.E.E.E. Baulieu E.E.E.E., Etudes Sur Le Mode D'action Des Hormones Steroides Sexuelles : Metabolisme Au Niveau Des Organes Cibles Et Liaison a Des Proteines Specifiques, Paris, New York: Gordon & Breach, 1974, ISBN 978-0-677-50650-0 .
- E.E.E.E. Baulieu E.E.E.E. i inni, Steroid-induced meiotic division in Xenopus laevis oocytes: surface and calcium, „Nature”, 275 (5681), 1978, s. 593–598, DOI: 10.1038/275593a0, PMID: 30046 .
- J.J. Finidori-Lepicard J.J. i inni, Progesterone inhibits membrane-bound adenylate cyclase in Xenopus laevis oocytes, „Nature”, 292 (5820), 1981, s. 255–257, DOI: 10.1038/292255a0, PMID: 7195984 .
- C.C. Corpéchot C.C. i inni, Characterization and measurement of dehydroepiandrosterone sulfate in rat brain, „Proceedings of the National Academy of Sciences of the United States of America”, 78 (8), 1981, s. 4704–4707, DOI: 10.1073/pnas.78.8.4704, PMID: 6458035, PMCID: PMC320231 .
- I.I. Joab I.I. i inni, Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones, „Nature”, 308 (5962), 1984, s. 850–853, DOI: 10.1038/308850a0, PMID: 6201744 .
- Jacques-LouisJ.L. Binet Jacques-LouisJ.L., Étienne-ÉmileÉ.É. Baulieu Étienne-ÉmileÉ.É., La Création vagabonde, Paris: Hermann, 1986, ISBN 2-7056-6051-8, OCLC 300913121 .
- E.E.E.E. Baulieu E.E.E.E., Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor, „Science”, 245 (4924), 1989, s. 1351–1357, DOI: 10.1126/science.2781282, PMID: 2781282 .
- Étienne-EmileÉ.E. Baulieu Étienne-EmileÉ.E., Génération pilule, Paris: Odile Jacob, 1990, ISBN 2-7381-0071-6, OCLC 417597744 .
- Etienne-EmileE.E. Baulieu Etienne-EmileE.E., Paul A.P.A. Kelly Paul A.P.A., Hormones. From Molecules to Disease, Paris: Hermann, 1990, ISBN 2-7056-6030-5, OCLC 21035089 .
- Etienne-EmileE.E. Baulieu Etienne-EmileE.E., MortM. Rosenblum MortM., The "abortion pill". RU-486, a woman's choice, New York: Simon & Schuster, 1991, ISBN 0-671-73816-X, OCLC 24288599 .
- ClaudeC. Debru ClaudeC., Etienne-EmileE.E. Baulieu Etienne-EmileE.E., Bio-éthique et cultures, Paris: Librairie philosophique J. Vrin, 1991, ISBN 2-7116-9725-8, OCLC 406701902 .
- M.C.M.C. Lebeau M.C.M.C. i inni, P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody, „Journal of Biological Chemistry”, 267 (7), 1992, s. 4281–4284, PMID: 1537818 .
- R.R. Peyron R.R. i inni, Early termination of pregnancy with mifepristone (RU 486) and the orally active prostaglandin misoprostol, „The New England Journal of Medicine”, 328 (21), 1993, s. 1509–1513, DOI: 10.1056/NEJM199305273282101, PMID: 8479487 .
- C.C. Radanyi C.C., B.B. Chambraud B.B., E.E.E.E. Baulieu E.E.E.E., The ability of the immunophilin FKBP59-HBI to interact with the 90-kDa heat shock protein is encoded by its tetratricopeptide repeat domain, „Proceedings of the National Academy of Sciences of the United States of America”, 91 (23), 1994, s. 11197–11201, DOI: 10.1073/pnas.91.23.11197, PMID: 7526392, PMCID: PMC45194 .
- H.L.H.L. Koenig H.L.H.L. i inni, Progesterone synthesis and myelin formation by Schwann cells, „Science”, 268 (5216), 1995, s. 1500–1503, DOI: 10.1126/science.7770777, PMID: 7770777 .
- C.C. Berr C.C. i inni, Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study, „Proceedings of the National Academy of Sciences of the United States of America”, 93 (23), 1996, s. 13410–13415, DOI: 10.1073/pnas.93.23.13410, PMID: 8917605, PMCID: PMC24107 .
- Étienne-EmileÉ.E. Baulieu Étienne-EmileÉ.E., FrançoiseF. Héritier FrançoiseF., HenriH. Leridon HenriH., Contraception. Contrainte ou liberté?, Paris: Odile Jacob, 1999, ISBN 2-7381-0722-2, OCLC 406793786 .
- B.B. Chambraud B.B. i inni, Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-COA alpha-hydroxylase is a new FKBP-associated protein, „Proceedings of the National Academy of Sciences of the United States of America”, 96 (5), 1999, s. 2104–2109, DOI: 10.1073/pnas.96.5.2104, PMID: 10051602, PMCID: PMC26744 .
- M.M. Schumacher M.M. i inni, Steroid synthesis and metabolism in the nervous system: trophic and protective effects, „Journal of Neurocytology”, 29 (5-6), 2000, s. 307–326, DOI: 10.1023/A:1007152904926, PMID: 11424948 .
- Y.Y. Akwa Y.Y. i inni, The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: distinct mechanisms?, „Proceedings of the National Academy of Sciences of the United States of America”, 98 (24), 2001, s. 14033–14037, DOI: 10.1073/pnas.241503698, PMID: 11717462, PMCID: PMC61162 .
- LiseL. Mazat LiseL. i inni, Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality, „Proceedings of the National Academy of Sciences of the United States of America”, 98 (14), 2001, s. 8145–8150, DOI: 10.1073/pnas.121177998, PMID: 11427700, PMCID: PMC35482 .
- FlorenceF. Broué FlorenceF. i inni, A steroid hormone that extends the lifespan of Caenorhabditis elegans, „Aging Cell”, 6 (1), 2007, s. 87–94, DOI: 10.1111/j.1474-9726.2006.00268.x, PMID: 17266678 .
Linki zewnętrzne
- Strona członkowska na witrynie Francuskiej Akademii Nauk