Alkohol dehidrogenaza (NADP+)
| Alkohol dehidrogenaza (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Alkohol dehidrogenaza (NADP+) tetramer, Clostridium beijerinckii | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.1.1.2 | ||||||||
| CAS broj | 9028-12-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Alkohol dehidrogenaza (NADP+) (EC 1.1.1.2, alkoholna dehidrogenaza (NADP+), aldehid reduktaza (NADPH2), NADP-alkohol dehidrogenaza, NADP+-aldehid reduktaza, NADP+-zavisni aldehid reduktaza, NADPH-aldehid reduktaza, NADPH-zavisni aldehid reduktaza, nonspecifična sukcinski semialdehid reduktaza, ALR 1, low-Km aldehid reduktaza, high-Km aldehid reduktaza, alkohol dehidrogenaza (NADP)) je enzim sa sistematskim imenom alkohol:NADP+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- alkohol + NADP+ aldehid + NADPH + H+
Alkoholna dehidrogenaza je protein cinka. Neki članovi ove grupe oksiduju samo primarne alkohole; drugi deluju takođe na sekundarne alkohole. Mogu da budu identični sa EC 1.1.1.19 (L-glukuronat reduktaza), EC 1.1.1.33 (mevaldat reduktaza (NADPH)) i EC 1.1.1.55 (laktaldehid reduktaza (NADPH)). Ovi enzimi su specifični u pogledu NADPH.
Reference
- ↑ Bosron, W.F. and Prairie, R.L. (1972). „Triphosphopyridine nucleotide-linked aldehyde reductase. I. Purification and properties of the enzyme from pig kidney cortex”. J. Biol. Chem. 247: 4480-4485. PMID 4402936.
- ↑ DeMoss, R. (1953). „Triphosphopyridine nucleotide-specific ethanol dehydrogenase from Leuconostoc mesenteroides”. Bacteriol. Proc.: 81-81.
- ↑ Reeves, R.E., Montalvo, F.E. and Lushbaugh, T.S. (1971). „Nicotinamide-adenine dinucleotide phosphate-dependent alcohol dehydrogenase. Enzyme from Entamoeba histolytica and some enzyme inhibitors”. Int. J. Biochem. 2: 55-64.
- ↑ Tabakoff, B. and Erwin, V.G. (1970). „Purification and characterization of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from brain”. J. Biol. Chem. 245: 3263-3268. PMID 4393513.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Vanjske veze
- MeSH Alcohol+dehydrogenase+(NADP+)
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
Alkohol dehidrogenaza (NADP+) na Wikimedijinoj ostavi
