POLD4
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| Polimeraza (DNK vođena), delta 4, pomoćna podjedinica | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | POLD4; POLDS; p12 | ||||||||||
| Vanjski ID | OMIM: 611525 MGI: 1916995 HomoloGene: 10909 GeneCards: POLD4 Gene | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 57804 | 69745 | |||||||||
| Ensembl | ENSG00000175482 | ENSMUSG00000024854 | |||||||||
| UniProt | Q9HCU8 | Q9CWP8 | |||||||||
| Ref. Sekv. (iRNK) | NM_001256870 | NM_027196 | |||||||||
| Ref. Sekv. (protein) | NP_001243799 | NP_081472 | |||||||||
| Lokacija (UCSC) | Chr 11: 67.12 - 67.12 Mb | Chr 19: 4.23 - 4.23 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Delta podjedinica 4 DNK polimeraze, takođe poznata kao delta podjedinica p12 DNK polimeraze, je protein koji je kod ljudi kodiran POLD4 genom.[1] Ona je komponeneta kompleksa DNK polimeraze delta.
Reference
- ↑ „Entrez Gene: polymerase (DNA-directed)”.
Literatura
- Xie B, Mazloum N, Liu L, et al. (2002). „Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme.”. Biochemistry 41 (44): 13133–42. DOI:10.1021/bi0262707. PMID 12403614.
- Selak N, Bachrati CZ, Shevelev I, et al. (2008). „The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.”. Nucleic Acids Res. 36 (16): 5166–79. DOI:10.1093/nar/gkn498. PMC 2532730. PMID 18682526.
- Bae SH, Bae KH, Kim JA, Seo YS (2001). „RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.”. Nature 412 (6845): 456–61. DOI:10.1038/35086609. PMID 11473323.
- Matsumoto Y, Kim K, Hurwitz J, et al. (1999). „Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins.”. J. Biol. Chem. 274 (47): 33703–8. DOI:10.1074/jbc.274.47.33703. PMID 10559261.
- Liu G, Warbrick E (2006). „The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins.”. Biochem. Biophys. Res. Commun. 349 (1): 360–6. DOI:10.1016/j.bbrc.2006.08.049. PMID 16934752.
- Tsurimoto T, Shinozaki A, Yano M, et al. (2005). „Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta.”. Genes Cells 10 (1): 13–22. DOI:10.1111/j.1365-2443.2004.00812.x. PMID 15670210.
- Wood RD, Shivji MK (1997). „Which DNA polymerases are used for DNA-repair in eukaryotes?”. Carcinogenesis 18 (4): 605–10. DOI:10.1093/carcin/18.4.605. PMID 9111189.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Huang QM, Akashi T, Masuda Y, et al. (2010). „Roles of POLD4, smallest subunit of DNA polymerase delta, in nuclear structures and genomic stability of human cells.”. Biochem. Biophys. Res. Commun. 391 (1): 542–6. DOI:10.1016/j.bbrc.2009.11.094. PMID 19931513.
- Li H, Xie B, Zhou Y, et al. (2006). „Functional roles of p12, the fourth subunit of human DNA polymerase delta.”. J. Biol. Chem. 281 (21): 14748–55. DOI:10.1074/jbc.M600322200. PMID 16510448.
- Liu L, Mo J, Rodriguez-Belmonte EM, Lee MY (2000). „Identification of a fourth subunit of mammalian DNA polymerase delta.”. J. Biol. Chem. 275 (25): 18739–44. DOI:10.1074/jbc.M001217200. PMID 10751307.
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i inicijacija
Prokariotska (inicijacija) | |
|---|---|
Eukariotska (priprema u G1 fazi) | |
Oba | Početak replikacije/Ori/Replikon Replikaciona viljuška (zaostajući i vodeći lanci) • Okazakijev fragment • Prajmer |
Prokariotska (elongacija) | DNK polimeraza III holoenzim (dnaC, dnaE, dnaH, dnaN, dnaQ, dnaT, dnaX, holA, holB, holC, holD, holE) • Replizom • DNK ligaza • DNK stega • Topoizomeraza (DNK giraza) Prokariotska DNK polimeraza: DNK polimeraza I (Klenov fragment) |
|---|---|
Eukariotska (sinteza u S fazi) | Replikacioni faktor C (RFC1, RFC2, RFC3, RFC4, RFC5) • Endonukleaza prepusta (FEN1) • Topoizomeraza • Replikacioni protein A (RPA1) Eukariotska DNK polimeraza: delta (POLD1, POLD2, POLD3, POLD4) DNK stega (PCNA) |
Oba |
B bsyn: dnk (repl, cycl, reco, repr) • tscr (fact, tcrg, nucl, rnat, rept, ptts) • tltn (risu, pttl, nexn) • dnab, rnab/runp • stru (domn, 1°, 2°, 3°, 4°)
