Neuregulin 4

Protein-coding gene in the species Homo sapiens
NRG4
Identifiers
AliasesNRG4, HRG4, neuregulin 4
External IDsOMIM: 610894; MGI: 1933833; HomoloGene: 12921; GeneCards: NRG4; OMA:NRG4 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for NRG4
Genomic location for NRG4
Band15q24.2Start75,935,969 bp[1]
End76,059,795 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for NRG4
Genomic location for NRG4
Band9|9 BStart55,127,506 bp[2]
End55,234,128 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • right uterine tube

  • cerebellar hemisphere

  • secondary oocyte

  • gastrocnemius muscle

  • Achilles tendon

  • right adrenal gland

  • Brodmann area 9

  • islet of Langerhans

  • hypothalamus
Top expressed in
  • brown adipose tissue

  • secondary oocyte

  • white adipose tissue

  • subcutaneous adipose tissue

  • intercostal muscle

  • mammary gland

  • lip

  • duodenum

  • ascending aorta

  • proximal tubule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • growth factor activity
  • protein tyrosine kinase activity
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity
  • signaling receptor binding
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • extracellular region
  • intracellular anatomical structure
  • extracellular space
Biological process
  • MAPK cascade
  • ERBB2 signaling pathway
  • phosphatidylinositol phosphate biosynthetic process
  • peptidyl-tyrosine phosphorylation
  • regulation of cell motility
  • intracellular signal transduction
  • animal organ development
  • regulation of signaling receptor activity
  • positive regulation of protein kinase B signaling
  • nervous system development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

145957

83961

Ensembl

ENSG00000169752

ENSMUSG00000032311

UniProt

Q8WWG1

Q9WTX4

RefSeq (mRNA)

NM_138573

NM_032002

RefSeq (protein)

NP_612640

NP_114391

Location (UCSC)Chr 15: 75.94 – 76.06 MbChr 9: 55.13 – 55.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.[5][6][7]

Function

The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 (ERBB4) to initiating cell signaling through cytosolic tyrosine phosphorylation.[7]

Clinical significance

Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169752 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032311 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NRG4 neuregulin 4".
  6. ^ Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  7. ^ a b Harari D, Tzahar E, Romano J, Shelly M, Pierce JH, Andrews GC, Yarden Y (April 1999). "Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase". Oncogene. 18 (17): 2681–9. doi:10.1038/sj.onc.1202631. PMID 10348342.
  8. ^ Memon AA, Sorensen BS, Melgard P, Fokdal L, Thykjaer T, Nexo E (December 2004). "Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients". Br. J. Cancer. 91 (12): 2034–41. doi:10.1038/sj.bjc.6602251. PMC 2409781. PMID 15583696.

Further reading

  • Révillion F, Lhotellier V, Hornez L, Bonneterre J, Peyrat JP (January 2008). "ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis". Ann. Oncol. 19 (1): 73–80. doi:10.1093/annonc/mdm431. PMID 17962208.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hayes NV, Newsam RJ, Baines AJ, Gullick WJ (2008). "Characterization of the cell membrane-associated products of the Neuregulin 4 gene". Oncogene. 27 (5): 715–20. doi:10.1038/sj.onc.1210689. PMID 17684490.
  • Hayes NV, Blackburn E, Smart LV, et al. (2007). "Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer". Clin. Cancer Res. 13 (11): 3147–55. doi:10.1158/1078-0432.CCR-06-2237. PMID 17545517.
  • v
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Angiopoietin
  • Kinase inhibitors: Altiratinib
  • CE-245677
  • Rebastinib
CNTF
EGF (ErbB)
EGF
(ErbB1/HER1)
ErbB2/HER2
  • Agonists: Unknown/none
ErbB3/HER3
ErbB4/HER4
FGF
FGFR1
FGFR2
  • Antibodies: Aprutumab
  • Aprutumab ixadotin
FGFR3
FGFR4
Unsorted
HGF (c-Met)
IGF
IGF-1
  • Kinase inhibitors: BMS-754807
  • Linsitinib
  • NVP-ADW742
  • NVP-AEW541
  • OSl-906
IGF-2
  • Antibodies: Dusigitumab
  • Xentuzumab (against IGF-1 and IGF-2)
Others
  • Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1)
  • Trofinetide
LNGF (p75NTR)
  • Aptamers: Against NGF: RBM-004
  • Decoy receptors: LEVI-04 (p75NTR-Fc)
PDGF
RET (GFL)
GFRα1
GFRα2
GFRα3
GFRα4
Unsorted
  • Kinase inhibitors: Agerafenib
SCF (c-Kit)
TGFβ
  • See here instead.
Trk
TrkA
  • Negative allosteric modulators: VM-902A
  • Aptamers: Against NGF: RBM-004
  • Decoy receptors: ReN-1820 (TrkAd5)
TrkB
TrkC
VEGF
Others


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