Verdamicin

Verdamicin
Klinički podaci

Drugs.com	Monografija
Identifikatori
CAS broj	49863-48-1^Y
ATC kod	none
PubChem	CID 512877
ChEMBL	CHEMBL1276546^Y
Sinonimi	(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[[(2S,3R)-3-amino-6-[(1S)-1-aminoethyl]-3,4-dihydro-2H-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-methylaminooxane-3,5-diol
Hemijski podaci
Formula	C₂₀H₃₉N₅O₇
Molarna masa	461,553
SMILES CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3OC(=CC[C@H]3N)[C@H](C)N)[C@@H]2O)OC[C@]1(C)O
InChI InChI=1S/C20H39N5O7/c1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19/h5,8-11,13-19,25-28H,4,6-7,21-24H2,1-3H3/t8-,9+,10-,11+,13-,14+,15+,16-,17+,18+,19+,20-/m0/s1^Y Key:XUSXOPRDIDWMFO-CTMSJIKGSA-N^Y

Verdamicin je organsko jedinjenje, koje sadrži 20 atoma ugljenika i ima molekulsku masu od 461,553 Da.

Osobine

Osobina	Vrednost
Broj akceptora vodonika	12
Broj donora vodonika	8
Broj rotacionih veza	6
Particioni koeficijent^[1] (ALogP)	-4,3
Rastvorljivost^[2] (logS, log(mol/L))	-1,2
Polarna površina^[3] (PSA, Å²)	213,7

^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Verdamicin na Vikimedijinoj ostavi.

Streptomyces	Streptomicin Neomicin (Framicetin, Paromomicin, Ribostamicin) Kanamicin (Amikacin, Arbekacin, Bekanamicin, Dibekacin, Tobramicin) Spektinomicin^# • Higromicin B Paromomicin
Micromonospora	Gentamicin^# (Netilmicin, Sisomicin, Isepamicin) Verdamicin Astromicin

Tetraciklini	Doksiciklin^# •Hlortetraciklin • Klomociklin • Demeklociklin • Limeciklin • Meklociklin • Metaciklin • Minociklin • Oksitetraciklin • Penimepiciklin • Rolitetraciklin • Tetraciklin
Glicilciklini	Tigeciklin

Amfenikoli	Hloramfenikol^# • Azidamfenikol • Tiamfenikol • Florfenikol
Pleuromutilini	Retapamulin • Tiamulin • Valnemulin

Makrolidi	Eritromicin^# • Azitromicin^# • Spiramicin • Midekamicin • Oleandomicin • Roksitromicin • Jozamicin • Troleandomicin • Klaritromicin • Miokamicin • Rokitamicin • Diritromicin • Fluritromicin • Ketolid (Telitromicin, Cetromicin)
Linkozamidi	Klindamicin^# • Linkomicin
Streptogramini	Pristinamicin • Hinupristin/dalfopristin • Virginijamicin