HIC1

Protein-coding gene in the species Homo sapiens
HIC1
Identifiers
AliasesHIC1, ZBTB29, ZNF901, hic-1, hypermethylated in cancer 1, HIC ZBTB transcriptional repressor 1
External IDsOMIM: 603825; MGI: 1338010; HomoloGene: 4740; GeneCards: HIC1; OMA:HIC1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for HIC1
Genomic location for HIC1
Band17p13.3Start2,054,154 bp[1]
End2,063,241 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for HIC1
Genomic location for HIC1
Band11 B5|11 45.76 cMStart75,055,391 bp[2]
End75,060,345 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • sural nerve

  • vena cava

  • left uterine tube

  • pericardium

  • canal of the cervix

  • anterior pituitary

  • myometrium

  • left ventricle

  • subcutaneous adipose tissue
Top expressed in
  • internal carotid artery

  • external carotid artery

  • vas deferens

  • female urethra

  • dermis

  • placenta

  • uterus

  • sclerotome

  • male urethra

  • left ventricle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • sequence-specific DNA binding
  • DNA binding
  • histone deacetylase binding
  • protein binding
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • chromatin
  • nucleus
  • cytosol
  • nucleoplasm
Biological process
  • multicellular organism development
  • negative regulation of Wnt signaling pathway
  • positive regulation of DNA damage response, signal transduction by p53 class mediator
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • Wnt signaling pathway
  • transcription, DNA-templated
  • intrinsic apoptotic signaling pathway in response to DNA damage
  • cellular response to DNA damage stimulus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3090

15248

Ensembl

ENSG00000177374

ENSMUSG00000043099

UniProt

Q14526

Q9R1Y5

RefSeq (mRNA)

NM_006497
NM_001098202

NM_001098203
NM_010430

RefSeq (protein)

NP_001091672
NP_006488

NP_001091673
NP_034560

Location (UCSC)Chr 17: 2.05 – 2.06 MbChr 11: 75.06 – 75.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177374 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043099 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: HIC1 hypermethylated in cancer 1".

Further reading

  • Chopin V, Leprince D (2006). "[Chromosome arm 17p13.3: could HIC1 be the one ?]". Med Sci (Paris). 22 (1): 54–61. doi:10.1051/medsci/200622154. PMID 16386221.
  • Wales MM, Biel MA, el Deiry W, et al. (1995). "p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3". Nat. Med. 1 (6): 570–7. doi:10.1038/nm0695-570. PMID 7585125. S2CID 21993943.
  • Fujii H, Biel MA, Zhou W, et al. (1998). "Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer". Oncogene. 16 (16): 2159–64. doi:10.1038/sj.onc.1201976. PMID 9572497.
  • Deltour S, Guerardel C, Stehelin D, Leprince D (1999). "The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved". Biochim. Biophys. Acta. 1443 (1–2): 230–2. doi:10.1016/s0167-4781(98)00219-x. PMID 9838134.
  • Deltour S, Guerardel C, Leprince D (2000). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14831–6. Bibcode:1999PNAS...9614831D. doi:10.1073/pnas.96.26.14831. PMC 24733. PMID 10611298.
  • Guerardel C, Deltour S, Pinte S, et al. (2001). "Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53". J. Biol. Chem. 276 (5): 3078–89. doi:10.1074/jbc.M008690200. PMID 11073960.
  • Deltour S, Pinte S, Guérardel C, Leprince D (2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1". Biochem. Biophys. Res. Commun. 287 (2): 427–34. doi:10.1006/bbrc.2001.5624. PMID 11554746.
  • Deltour S, Pinte S, Guerardel C, et al. (2002). "The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif". Mol. Cell. Biol. 22 (13): 4890–901. doi:10.1128/MCB.22.13.4890-4901.2002. PMC 133903. PMID 12052894.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583.
  • Rathi A, Virmani AK, Harada K, et al. (2004). "Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms". Clin. Cancer Res. 9 (10 Pt 1): 3674–8. PMID 14506157.
  • Waha A, Waha A, Koch A, et al. (2004). "Epigenetic silencing of the HIC-1 gene in human medulloblastomas". J. Neuropathol. Exp. Neurol. 62 (11): 1192–201. doi:10.1093/jnen/62.11.1192. PMID 14656076.
  • Lindsey JC, Lusher ME, Anderton JA, et al. (2004). "Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling". Carcinogenesis. 25 (5): 661–8. doi:10.1093/carcin/bgh055. PMID 14688019.
  • Pinte S, Guérardel C, Deltour-Balerdi S, et al. (2004). "Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1". Oncogene. 23 (22): 4023–31. doi:10.1038/sj.onc.1207504. PMID 15007385.
  • Pinte S, Stankovic-Valentin N, Deltour S, et al. (2004). "The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties". J. Biol. Chem. 279 (37): 38313–24. doi:10.1074/jbc.M401610200. PMID 15231840.
  • Chen W, Cooper TK, Zahnow CA, et al. (2004). "Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis". Cancer Cell. 6 (4): 387–98. doi:10.1016/j.ccr.2004.08.030. PMID 15488761.
  • Britschgi C, Rizzi M, Grob TJ, et al. (2006). "Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1". Oncogene. 25 (14): 2030–9. doi:10.1038/sj.onc.1209240. PMID 16301995. S2CID 27624320.
  • Valenta T, Lukas J, Doubravska L, et al. (2006). "HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies". EMBO J. 25 (11): 2326–37. doi:10.1038/sj.emboj.7601147. PMC 1478201. PMID 16724116.
  • Stankovic-Valentin N, Verger A, Deltour-Balerdi S, et al. (2006). "A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP". FEBS J. 273 (13): 2879–90. doi:10.1111/j.1742-4658.2006.05301.x. PMID 16762039. S2CID 34249691.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
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  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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