ZNF346

ZNF346
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MKD, 2MKN
Identifiers
Aliases	ZNF346, JAZ, Zfp346, zinc finger protein 346
External IDs	OMIM: 605308 MGI: 1349417 HomoloGene: 8073 GeneCards: ZNF346
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 177,022,696 bp[1] End 177,081,189 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 55,105,311 bp[2] End 55,134,825 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell sural nerve ganglionic eminence Achilles tendon tibialis anterior muscle prefrontal cortex oocyte left lobe of thyroid gland smooth muscle tissue blood Top expressed in spermatocyte extraocular muscle superior frontal gyrus thymus cerebellar cortex adrenal gland right ventricle seminiferous tubule temporal muscle thoracic diaphragm More reference expression data BioGPS n/a
Gene ontology Molecular function enzyme binding double-stranded RNA binding zinc ion binding p53 binding protein binding metal ion binding nucleic acid binding RNA binding miRNA binding Cellular component cytoplasm nucleolus nucleus Biological process intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23567 26919 Ensembl ENSG00000113761 ENSMUSG00000021481 UniProt Q9UL40 Q9R0B7 RefSeq (mRNA) NM_001308213 NM_001308214 NM_001308215 NM_001308216 NM_001308218 NM_001308219 NM_001308221 NM_001308223 NM_012279 NM_001363713 NM_012017 RefSeq (protein) NP_001295142 NP_001295143 NP_001295144 NP_001295145 NP_001295147 NP_001295148 NP_001295150 NP_001295152 NP_036411 NP_001350642 NP_036147 NP_001365863 NP_001365864 Location (UCSC) Chr 5: 177.02 – 177.08 Mb Chr 13: 55.11 – 55.13 Mb PubMed search [3] [4]
Wikidata
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Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.^[5][6]

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival.^[6]

References

Further reading

External links

• ZNF346+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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