Nadoxolol

Nadoxolol
Names
IUPAC name
N,3-Dihydroxy-4-naphthalen-1-yloxybutanimidamide
Identifiers
CAS Number
  • 54063-51-3 checkY
  • 35991-93-6 (hydrochloride) checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 4886543
EC Number
  • 252-825-2
MeSH C006154
PubChem CID
  • 6328253
UNII
  • SK43HU1689 checkY
  • RZ9G589EN2 checkY
CompTox Dashboard (EPA)
  • DTXSID90968903 Edit this at Wikidata
InChI
  • InChI=1S/C14H16N2O3/c15-14(16-18)8-11(17)9-19-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11,17-18H,8-9H2,(H2,15,16)
    Key: UPZVYDSBLFNMLK-UHFFFAOYSA-N
  • InChI=1/C14H16N2O3/c15-14(16-18)8-11(17)9-19-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11,17-18H,8-9H2,(H2,15,16)
    Key: UPZVYDSBLFNMLK-UHFFFAOYAW
  • C1=CC=C2C(=C1)C=CC=C2OCC(C/C(=N/O)/N)O
Properties
Chemical formula
C14H16N2O3
Molar mass 260.293 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound

Nadoxolol is an antiarrhythmic agent (i.e., a drug for the treatment of irregular heartbeat),[1] chemically related in structure to beta-adrenergic receptor blocker drugs such as propranolol.[2]

It does not appear to be marketed anywhere in the world.

References

  1. ^ Warembourg, H; Ducloux, G (1976). "Clinical study of a new anti-arrhythmia agent: nadoxolol". Lille Med. 21 (4): 386–8. PMID 957857.
  2. ^ Kapoor, M; Anand, N; Koul, S; Chimni, SS; Manhas, KS; Raina, C; Parshad, R; Taneja, SC; Qazi, GN (2003). "Kinetic resolution of 1-chloro-3-(1-naphthyloxy)-2-propanol, an intermediate in the synthesis of beta-adrenergic receptor blockers". Bioorganic Chemistry. 31 (3): 259–69. doi:10.1016/s0045-2068(03)00050-6. PMID 12818235.
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Adrenergic receptor modulators
α1
Agonists
Antagonists
α2
Agonists
Antagonists
β
Agonists
Antagonists
  • See also: Receptor/signaling modulators
  • Dopaminergics
  • Serotonergics
  • Monoamine reuptake inhibitors
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  • Monoamine neurotoxins
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Channel blockers
class I
(Na+ channel blockers)
class Ia (Phase 0→ and Phase 3→)
class Ib (Phase 3←)
class Ic (Phase 0→)
class III
(Phase 3→, K+ channel blockers)
class IV
(Phase 4→, Ca2+ channel blockers)
Receptor agonists
and antagonists
class II
(Phase 4→, β blockers)
A1 agonist
M2
α receptors
Ion transporters
Na+/ K+-ATPase
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