EPHB3

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EPH receptor B3
Dostupne strukture
3P1I, 3ZFY
Identifikatori
SimboliEPHB3; ETK2; HEK2; TYRO6
Vanjski IDOMIM: 601839 MGI: 104770 HomoloGene: 20938 GeneCards: EPHB3 Gene
EC broj2.7.10.1
Ontologija gena
Molekulska funkcija • aktivnost efrinskog receptora
• ATP vezivanje
• receptorska aktivnost aksonskog navođenja
Ćelijska komponenta • integralna komponenta ćelijske membrane
• dendrit
Biološki proces • angiogeneza
• razviće urogenitalnog sistema
• aksonsko navođenje
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez204913845
EnsemblENSG00000182580ENSMUSG00000005958
UniProtP54753P54754
Ref. Sekv. (iRNK)NM_004443NM_010143
Ref. Sekv. (protein)NP_004434NP_034273
Lokacija (UCSC)Chr 3:
184.28 - 184.3 Mb		Chr 16:
21.2 - 21.22 Mb
PubMed pretraga[1][2]

Receptor 3 efrinskog tipa B je protein koji je kod ljudi kodiran EPHB3 genom.[1][2]

Efrinski receptori i njihovi ligandi, efrini, posreduju brojne procese razvića, posebno u nervnom sistemu. Na bazi njihovih struktura i sekvenci, efrini se dele u efrinsku klasu A (EFNA), koja se fiksira na membrani putem glikozilfosfatidilinozitolne veze, i efrinsku klasu B (EFNB), koji su transmembranski proteini. Eph familija receptora se deli u dve groupe na osnovu sličnosti njihovih sekvenci ekstracelularnog domena i njihovog afiniteta vezivanja liganda efrina A i efrina B. Efrinski receptori su najveća podgrupa receptora tirozinske kinazne (RTK) familije. Protein kodiran ovim genom je receptor za efrinske-B članove familije.[2]

Interakcije

EPHB3 formira interakcije sa MLLT4[3] i RAS p21 proteinskim aktivatorom 1.[4]

Reference

  1. ↑ Bohme B, Holtrich U, Wolf G, Luzius H, Grzeschik KH, Strebhardt K, Rubsamen-Waigmann H (Oct 1993). „PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2”. Oncogene 8 (10): 2857–62. PMID 8397371. 
  2. ↑ 2,0 2,1 „Entrez Gene: EPHB3 EPH receptor B3”. 
  3. ↑ Hock, B; Böhme B; Karn T; Yamamoto T; Kaibuchi K; Holtrich U; Holland S; Pawson T i dr.. (Aug 1998). „PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (17): 9779–84. DOI:10.1073/pnas.95.17.9779. ISSN 0027-8424. PMC 21413. PMID 9707552. 
  4. ↑ Hock, B; Böhme B; Karn T; Feller S; Rübsamen-Waigmann H; Strebhardt K (Jul 1998). „Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions”. Oncogene (ENGLAND) 17 (2): 255–60. DOI:10.1038/sj.onc.1201907. ISSN 0950-9232. PMID 9674711. 

Literatura

  • Flanagan JG, Vanderhaeghen P (1998). „The ephrins and Eph receptors in neural development.”. Annu. Rev. Neurosci. 21: 309–45. DOI:10.1146/annurev.neuro.21.1.309. PMID 9530499. 
  • Zhou R (1998). „The Eph family receptors and ligands.”. Pharmacol. Ther. 77 (3): 151–81. DOI:10.1016/S0163-7258(97)00112-5. PMID 9576626. 
  • Holder N, Klein R (1999). „Eph receptors and ephrins: effectors of morphogenesis.”. Development 126 (10): 2033–44. PMID 10207129. 
  • Wilkinson DG (2000). „Eph receptors and ephrins: regulators of guidance and assembly.”. Int. Rev. Cytol. 196: 177–244. DOI:10.1016/S0074-7696(00)96005-4. PMID 10730216. 
  • Xu Q, Mellitzer G, Wilkinson DG (2001). „Roles of Eph receptors and ephrins in segmental patterning.”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. DOI:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993. 
  • Wilkinson DG (2001). „Multiple roles of EPH receptors and ephrins in neural development.”. Nat. Rev. Neurosci. 2 (3): 155–64. DOI:10.1038/35058515. PMID 11256076. 
  • Böhme B, VandenBos T, Cerretti DP, et al. (1996). „Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.”. J. Biol. Chem. 271 (40): 24747–52. DOI:10.1074/jbc.271.40.24747. PMID 8798744. 
  • Ephnomenclaturecommittee, (1997). „Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.”. Cell 90 (3): 403–4. DOI:10.1016/S0092-8674(00)80500-0. PMID 9267020. 
  • Bergemann AD, Zhang L, Chiang MK, et al. (1998). „Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube.”. Oncogene 16 (4): 471–80. DOI:10.1038/sj.onc.1201557. PMID 9484836. 
  • Hock B, Böhme B, Karn T, et al. (1998). „Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions.”. Oncogene 17 (2): 255–60. DOI:10.1038/sj.onc.1201907. PMID 9674711. 
  • Hock B, Böhme B, Karn T, et al. (1998). „PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. DOI:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552. 
  • Ciossek T, Monschau B, Kremoser C, et al. (1998). „Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro.”. Eur. J. Neurosci. 10 (5): 1574–80. DOI:10.1046/j.1460-9568.1998.00180.x. PMID 9751130. 
  • Adams RH, Wilkinson GA, Weiss C, et al. (1999). „Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.”. Genes Dev. 13 (3): 295–306. DOI:10.1101/gad.13.3.295. PMC 316426. PMID 9990854. 
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Receptori faktora rasta
EGFR • ERBB2 • ERBB3 • ERBB4
IGF1R • INSR • INSRR
CSF1R • FLT3 • KIT • PDGFR (PDGFRA, PDGFRB)
FGFR1 • FGFR2 • FGFR3 • FGFR4
VEGFR1 • VEGFR2 • VEGFR3 • VEGFR4
MET • RON
NTRK1 • NTRK2 • NTRK3
EPH receptorska familija
EPHA1 • EPHA2 • EPHA3 • EPHA4 • EPHA5 • EPHA6 • EPHA7 • EPHA8 • EPHB1 • EPHB2 • EPHB3 • EPHB4 • EPHB5 • EPHB6 • EPHX
LTK receptorska familija
LTK • ALK
TIE receptorska familija
TIE • TEK
ROR receptorska familija
ROR1 • ROR2
DDR receptorska familija
DDR1 • DDR2
PTK7 receptorska familija
RYK receptorska familija
MuSK receptorska familija
ROS receptorska familija
ROS1
AATYK receptorska familija
AATYK • AATYK2 • AATYK3
AXL receptorska familija
AXL • MER • TYRO3
RET receptorska familija
nekategorisani
  • p
  • r
  • u
ABL familija
ABL1 • ARG
ACK familija
ACK1 • TNK1
CSK familija
CSK • MATK
FAK familija
FAK • PYK2
FES familija
FES • FER
FRK familija
FRK • BRK • SRMS
JAK familija
JAK1 • JAK2 • JAK3 • TYK2
SRC-A familija
SRC • FGR • FYN • YES1
SRC-B familija
BLK • HCK • LCK • LYN
TEC familija
TEC • BMX • BTK • ITK • TXK
SYK familija
SYK • ZAP70
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6