FZD5

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Uvojiti receptor 5
Identifikatori
SimboliFZD5; C2orf31; HFZ5
Vanjski IDOMIM: 601723 MGI: 108571 HomoloGene: 2590 IUPHAR: FZD5 GeneCards: FZD5 Gene
Ontologija gena
Molekularna funkcija • aktivnost G protein spregnutog receptora
• receptorsko vezivanje
• proteinsko vezivanje
• Wnt proteinsko vezivanje
• vezivanje PDZ domena
Celularna komponenta • citoplazma
• ćelijska površina
• integralno sa membranom
• sinaptosom
• membrana neuronske projekcije
Biološki proces • pozitivna regulacija proteinske fosforilacije
• razvoj vaskulature
• morfogeneza odlivnog trakta
• signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez785514367
EnsemblENSG00000163251ENSMUSG00000045005
UniProtQ13467Q9EQD0
RefSeq (mRNA)NM_003468.3NM_001033193.1
RefSeq (protein)NP_003459.2NP_001036124.1
Lokacija (UCSC)Chr 2:
208.63 - 208.63 Mb		Chr 1:
64.78 - 64.78 Mb
PubMed pretraga[1][2]

Uvojiti-5 je protein koji je kod ljudi kodiran FZD5 genom.[1][2][3]

Reference

  1. ↑ Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). „A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled”. J Biol Chem 271 (8): 4468–76. DOI:10.1074/jbc.271.8.4468. PMID 8626800. 
  2. ↑ Saitoh T, Hirai M, Katoh M (Jun 2001). „Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region”. Int J Oncol 19 (1): 105–10. PMID 11408929. 
  3. ↑ „Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)”. 

Literatura

  • He X, Saint-Jeannet JP, Wang Y, et al. (1997). „A member of the Frizzled protein family mediating axis induction by Wnt-5A.”. Science 275 (5306): 1652–4. DOI:10.1126/science.275.5306.1652. PMID 9054360. 
  • Finch PW, He X, Kelley MJ, et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. DOI:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640. 
  • Tanaka S, Akiyoshi T, Mori M, et al. (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. DOI:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618. 
  • Tamai K, Semenov M, Kato Y, et al. (2000). „LDL-receptor-related proteins in Wnt signal transduction.”. Nature 407 (6803): 530–5. DOI:10.1038/35035117. PMID 11029007. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). „Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”. Genome Res. 11 (3): 422–35. DOI:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. 
  • Yao R, Maeda T, Takada S, Noda T (2001). „Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.”. Biochem. Biophys. Res. Commun. 286 (4): 771–8. DOI:10.1006/bbrc.2001.5430. PMID 11520064. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Weidler C, Schaumburger J, Miller LE, et al. (2004). „Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation.”. J. Rheumatol. 31 (9): 1874–5. PMID 15338479. 
  • Omoto S, Hayashi T, Kitahara K, et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539. 
  • Holmen SL, Robertson SA, Zylstra CR, Williams BO (2005). „Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein.”. Biochem. Biophys. Res. Commun. 328 (2): 533–9. DOI:10.1016/j.bbrc.2005.01.009. PMID 15694380. 
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). „Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”. Nature 434 (7034): 724–31. DOI:10.1038/nature03466. PMID 15815621. 
  • Blumenthal A, Ehlers S, Lauber J, et al. (2006). „The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.”. Blood 108 (3): 965–73. DOI:10.1182/blood-2005-12-5046. PMID 16601243. 
  • Yamamoto H, Komekado H, Kikuchi A (2006). „Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.”. Dev. Cell 11 (2): 213–23. DOI:10.1016/j.devcel.2006.07.003. PMID 16890161. 
  • Katoh Y, Katoh M (2007). „Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer.”. Int. J. Oncol. 30 (3): 751–5. PMID 17273778. 

Vidi još

Spoljašnje veze

  • „Frizzled Receptors: FZD5”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-06-25. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)