Melanin-koncentrirajući hormonski receptor 2
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| Melanin-koncentrirajući hormonski receptor 2 | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | MCHR2; MCH2; GPR145; MCH2R; SLT | ||||||||||
| Vanjski ID | OMIM: 606111 HomoloGene: 50004 IUPHAR: MCH2 GeneCards: MCHR2 Gene | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 84539 | n/a | |||||||||
| Ensembl | ENSG00000152034 | n/a | |||||||||
| UniProt | Q969V1 | n/a | |||||||||
| RefSeq (mRNA) | NM_001040179 | n/a | |||||||||
| RefSeq (protein) | NP_001035269 | n/a | |||||||||
| Lokacija (UCSC) | Chr 6: 100.47 - 100.55 Mb | n/a | |||||||||
| PubMed pretraga | [1] | n/a | |||||||||
Melanin-koncentrirajući hormonski receptor 2, takođe poznat kao MCH2, je ljudski gen, i receptor.[1] MCH2 je nađen kod ljudi, pasa, feretki, i nekih drugih primata i mesojeda, ali nije nađen kod miševa i pacova. Ovo je usporilo istraživanja na upotrebi ovog receptora kao terapeutske mete, pošto se većina ranih farmaceutskih istraživanja obično izvodi na malim sisarima kao što su miševi, pacovi, ili zečevi.
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Literatura
- ↑ „Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2”.
Dodatna literatura
- Hill J, Duckworth M, Murdock P, et al. (2001). „Molecular cloning and functional characterization of MCH2, a novel human MCH receptor.”. J. Biol. Chem. 276 (23): 20125–9. DOI:10.1074/jbc.M102068200. PMID 11274220.
- Mori M, Harada M, Terao Y, et al. (2001). „Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor.”. Biochem. Biophys. Res. Commun. 283 (5): 1013–8. DOI:10.1006/bbrc.2001.4893. PMID 11355873.
- Sailer AW, Sano H, Zeng Z, et al. (2001). „Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.”. Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7564–9. DOI:10.1073/pnas.121170598. PMC 34708. PMID 11404457.
- An S, Cutler G, Zhao JJ, et al. (2001). „Identification and characterization of a melanin-concentrating hormone receptor.”. Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7576–81. DOI:10.1073/pnas.131200698. PMC 34710. PMID 11416225.
- Wang S, Behan J, O'Neill K, et al. (2001). „Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2.”. J. Biol. Chem. 276 (37): 34664–70. DOI:10.1074/jbc.M102601200. PMID 11459838.
- Bednarek MA, Feighner SD, Hreniuk DL, et al. (2001). „Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.”. Biochemistry 40 (31): 9379–86. DOI:10.1021/bi010867p. PMID 11478907.
- Bednarek MA, Tan C, Hreniuk DL, et al. (2002). „Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.”. J. Biol. Chem. 277 (16): 13821–6. DOI:10.1074/jbc.M200563200. PMID 11839762.
- Audinot V, Lahaye C, Suply T, et al. (2002). „SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor.”. Biochem. Biophys. Res. Commun. 295 (4): 841–8. DOI:10.1016/S0006-291X(02)00763-5. PMID 12127971.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Logan DW, Bryson-Richardson RJ, Pagán KE, et al. (2003). „The structure and evolution of the melanocortin and MCH receptors in fish and mammals.”. Genomics 81 (2): 184–91. DOI:10.1016/S0888-7543(02)00037-X. PMID 12620396.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). „The DNA sequence and analysis of human chromosome 6.”. Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Vitale RM, Pedone C, De Benedetti PG, Fanelli F (2004). „Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.”. Proteins 56 (3): 430–48. DOI:10.1002/prot.20125. PMID 15229878.
- Hawes BE, Green B, O'Neill K, et al. (2004). „Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.”. Obes. Res. 12 (8): 1327–34. DOI:10.1038/oby.2004.167. PMID 15340116.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- „Melanin-Concentrating Hormone Receptors: MCH2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
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Drugi | Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2) |
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glutamat / feromon
Drugi |
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Frizzled / Zaglađeni
Uvojiti | |
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Zaglađeni |
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
