FUT6

FUT6
Identifikatori
AlijasiFUT6
Spoljašnji IDOMIM: 136836 HomoloGene: 34780 GeneCards: FUT6
Obrazac RNK izražavanja


More reference expression data
Genska ontologija
Molecular function• transferase activity
• alpha-(1->3)-fucosyltransferase activity
• 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
• glycosyltransferase activity
• fucosyltransferase activity
Cellular component• саставни део мембране
• Golgi cisterna membrane
• Голџијев апарат
• extracellular exosome
• мембрана
• Golgi membrane
Biological process• GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation
• L-fucose catabolic process
• fucosylation
• ceramide metabolic process
Sources:Amigo / QuickGO
Ortolozi
VrsteČovekMiš
Entrez

2528

n/a

Ensembl

ENSG00000156413

n/a

UniProt

P51993

n/a

RefSeq (mRNA)
NM_000150
NM_001040701
NM_001369502
NM_001369504
NM_001369505

NM_001381955
NM_001381956
NM_001381957
NM_001381958
NM_001381959

n/a

RefSeq (protein)
NP_000141
NP_001035791
NP_001356431
NP_001356433
NP_001356434

NP_001368884
NP_001368885
NP_001368886
NP_001368887
NP_001368888

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Fukoziltransferaza 6 je enzim koji je kod ljudi kodiran genom FUT6.[2][3][4]

Alfa-1,3-fukoziltransferaze sačinjavaju veliku familiju glikoziltransferaza sa visokim stepenom homologije. Enzimi ove porodice se sastoje od 3 glavna obrasca aktivnosti koji se nazivaju mijeloid, plazma i Luis, zasnovan na njihovom kapacitetu da prenesu alfa-L-fukozu na različite akceptore oligosaharida, njihovoj osetljivosti na inhibiciju N-etilmaleimida, njihovim potrebama za katjonima i njihovim tkivno specifičnim obrascima izražavanja. Različite kategorije alfa-1,3-fukoziltransferaza se sekvencijalno izražavaju tokom embrio-fetusnog razvoja.[4]

Reference

  1. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  2. ^ Koszdin KL, Bowen BR (октобар 1992). „The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand”. Biochem Biophys Res Commun. 187 (1): 152—7. PMID 1520296. doi:10.1016/S0006-291X(05)81472-X. CS1 одржавање: Формат датума (веза)
  3. ^ McCurley RS, Recinos A III, Olsen AS, Gingrich JC, Szczepaniak D, Cameron HS, Krauss R, Weston BW (јул 1995). „Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21”. Genomics. 26 (1): 142—6. PMID 7782074. doi:10.1016/0888-7543(95)80094-3. CS1 одржавање: Формат датума (веза)
  4. ^ а б „Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)”. 

Literatura

  • Weston BW, Smith PL, Kelly RJ, Lowe JB (1992). „Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes.”. J. Biol. Chem. 267 (34): 24575—84. PMID 1339443. doi:10.1016/S0021-9258(18)35803-4 Слободан приступ. 
  • Cameron HS, Szczepaniak D, Weston BW (1995). „Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.”. J. Biol. Chem. 270 (34): 20112—22. PMID 7650030. doi:10.1074/jbc.270.34.20112 Слободан приступ. 
  • Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene. 138 (1–2): 171—4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8. 
  • Mollicone R, Reguigne I, Fletcher A, et al. (1994). „Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6).”. J. Biol. Chem. 269 (17): 12662—71. PMID 8175676. doi:10.1016/S0021-9258(18)99927-8 Слободан приступ. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.”. Gene. 200 (1–2): 149—56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3. 
  • Borsig L, Imbach T, Höchli M, Berger EG (2000). „alpha1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with beta1,4galactosyltransferase I in the golgi apparatus and monensin-induced swollen vesicles.”. Glycobiology. 9 (11): 1273—80. PMID 10536043. doi:10.1093/glycob/9.11.1273 Слободан приступ. 
  • Schnyder-Candrian S, Borsig L, Moser R, Berger EG (2000). „Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cells.”. Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8369—74. Bibcode:2000PNAS...97.8369S. PMC 26954 Слободан приступ. PMID 10900002. doi:10.1073/pnas.97.15.8369 Слободан приступ. 
  • Kamińska J, Musielak M, Nowicka A, et al. (2001). „Neutrophils promote the release of alpha-6-fucosyltransferase from blood platelets through the action of cathepsin G and elastase.”. Biochimie. 83 (8): 739—42. PMID 11530205. doi:10.1016/S0300-9084(01)01306-2. 
  • Roos C, Kolmer M, Mattila P, Renkonen R (2002). „Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.”. J. Biol. Chem. 277 (5): 3168—75. PMID 11698403. doi:10.1074/jbc.M107927200 Слободан приступ. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899 Слободан приступ. 
  • Kanoh A, Ota M, Narimatsu H, Irimura T (2003). „Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion.”. Biochem. Biophys. Res. Commun. 303 (3): 896—901. PMID 12670495. doi:10.1016/S0006-291X(03)00420-0. 
  • Martinez-Duncker I, Michalski JC, Bauvy C, et al. (2004). „Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.”. Glycobiology. 14 (1): 13—25. PMID 14514715. doi:10.1093/glycob/cwh006 Слободан приступ. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285 Слободан приступ. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”. Genome Res. 16 (1): 55—65. PMC 1356129 Слободан приступ. PMID 16344560. doi:10.1101/gr.4039406. 
  • Higai K, Miyazaki N, Azuma Y, Matsumoto K (2007). „Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene.”. FEBS Lett. 580 (26): 6069—75. PMID 17054948. S2CID 9731951. doi:10.1016/j.febslet.2006.09.073. 
  • п
  • р
  • у
2.4.1: Heksozil-
transferaze
Glukozil-
Galaktozil-
Glukuronozil-
Fukozil-
Manozil-
2.4.2: Pentozil-
transferaze
Riboza
ADP-riboziltransferaza
Fosforiboziltransferaza
Drugi
Drugi
2.4.99: Sijalil
transferaze