Bombezinu-sličan receptor 3

Bombezinu-sličan receptor 3‎

Identifikatori

BRS3;

Vanjski ID

OMIM: 300107 MGI: 1100501 HomoloGene: 1307 IUPHAR: BB₃ GeneCards: BRS3 Gene

Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • aktivnost bombezinskog receptora
Celularna komponenta	• ćelijska membrana • integralno sa membranom
Biološki proces	• glukozni metabolički proces • kontrakcija glatkih mišića • prenos signala • signalni put G-protein spregnutog receptora • response na nutrijente • regulacija krvnog pritiska • način ishrane odraslih osoba

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

680

12209

Ensembl

ENSG00000102239

ENSMUSG00000031130

UniProt

P32247

O54798

RefSeq (mRNA)

NM_001727

NM_009766

RefSeq (protein)

NP_001718

NP_033896

Lokacija (UCSC)

Chr X:
135.4 - 135.4 Mb

Chr X:
53.39 - 53.4 Mb

PubMed pretraga

[1]

[2]

Bombezinu-sličan receptor 3 (BRS-3, BB₃)^[1] je protein koji je kod ljudi kodiran BRS3 genom.^[2]^[3]

Funkcija

Kod sisara su bombezinu-slični peptidi široko rasprostranjeni u centralnom nervnom sistemu, kao i u gastrointenstinalnom traktu, gde oni modulišu kontrakcije glatkih mišića, eksokrine i endokrine procese, metabolizam, i ponašanje. Oni deluju putem vezivanja za G protein-spregnute receptore na ćelijskoj površni. Bombezinu-slični peptidni receptori su gastrin-oslobađajući peptidni receptor, neuromedinski B receptor, i bombezinu-sličan receptor-3.^[3]^[4]

BB₃ je G protein-spregnuti receptor,^[5] koji ima nizak afinitet za prirodne bombezinu-srodne peptide. Njegov endogeni ligand visokog afiniteta nije poznat, te je ovaj receptor klasifikovan kao orfanski receptor.^[2]^[6]^[7]

Literatura

^ „Bombesin Receptors: BB₃”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.
^ ^а ^б Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (1993). „BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells”. J. Biol. Chem. 268 (8): 5979—84. PMID 8383682.
^ ^а ^б Ohki-Hamazaki H, Wada E, Matsui K, Wada K (1997). „Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse”. Brain Res. 762 (1-2): 165—72. PMID 9262170. doi:10.1016/S0006-8993(97)00380-6.
^ „Entrez Gene: BRS3 bombesin-like receptor 3”.
^ Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (1993). „BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells”. J. Biol. Chem. 268 (8): 5979—84. PMID 8383682. Архивирано из оригинала 27. 12. 2007. г. Приступљено 04. 06. 2011.
^ Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT (1997). „Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors.”. J. Biol. Chem. 272 (41): 26062—26071. PMID 9325344. doi:10.1074/jbc.272.41.26062.
^ Jensen RT, Battey JF, Spindel ER, Benya RV (2007). „International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states.”. Pharmacol. Rev. 60 (1): 1—42. PMC 2517428 . PMID 18055507. doi:10.1124/pr.107.07108.

Dodatna literatura

Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F (1994). „Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus.”. FEBS Lett. 340 (3): 260—4. PMID 8131855. doi:10.1016/0014-5793(94)80150-9.
Fathi, Z.; Corjay, M. H.; Shapira, H.; et al. (1993). „BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells.”. J. Biol. Chem. 268 (8): 5979—84. PMID 8383682.
Kane, M. A.; Toi-Scott M; Johnson, G. L.; et al. (1996). „Bombesin-like peptide receptors in human bronchial epithelial cells.”. Peptides. 17 (1): 111—8. PMID 8822519. doi:10.1016/0196-9781(95)02088-8.
Ohki-Hamazaki H; Watase, K.; K, Yamamoto; et al. (1997). „Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity.”. Nature. 390 (6656): 165—9. PMID 9367152. doi:10.1038/36568.
Ryan, R. R.; Weber, H. C.; Hou, W.; et al. (1998). „Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3.”. J. Biol. Chem. 273 (22): 13613—24. PMID 9593699. doi:10.1074/jbc.273.22.13613.
Liu, J.; Lao, Z. J.; Zhang, J.; et al. (2002). „Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3).”. Biochemistry. 41 (28): 8954—60. PMID 12102638. doi:10.1021/bi0202777.
Ross, M. T.; Grafham, D. V.; Coffey, A. J.; et al. (2005). „The DNA sequence of the human X chromosome.”. Nature. 434 (7031): 325—37. PMC 2665286 . PMID 15772651. doi:10.1038/nature03440.
Hou X, Wei L, Harada A, Tatamoto K (2007). „Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells.”. Lung Cancer. 54 (2): 143—8. PMID 16979789. doi:10.1016/j.lungcan.2006.08.005.
Tan, Y. R.; Qin, X. Q.; Xiang, Y.; et al. (2007). „PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells.”. Biochem. J. 405 (1): 131—7. PMC 1925247 . PMID 17355223. doi:10.1042/BJ20061754.

Spoljašnje veze

„Bombesin Receptors: BB₃”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.
bombesin+receptor+subtype+3 на US National Library of Medicine Medical Subject Headings (MeSH)

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)