GPR15

G protein-spregnuti receptor 15

Identifikatori

GPR15; MGC126828; MGC126830

Vanjski ID

OMIM: 601166 MGI: 1918473 HomoloGene: 3869 IUPHAR: GPR15 GeneCards: GPR15 Gene

Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • aktivnost purinergičkog nukleotidnog receptora, G-protein spregnutog
Celularna komponenta	• integralno sa ćelijskom membranom • membrana
Biološki proces	• prenos signala • signalni put G-protein spregnutog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

2838

71223

Ensembl

ENSG00000154165

ENSMUSG00000047293

UniProt

P49685

n/a

RefSeq (mRNA)

NM_005290

XM_001002039

RefSeq (protein)

NP_005281

XP_001002039

Lokacija (UCSC)

Chr 3:
99.73 - 99.73 Mb

Chr 16:
58.66 - 58.66 Mb

PubMed pretraga

[1]

[2]

GPR15, G-protein spregnuti receptor 15, je protein koji je kod čoveka kodiran GPR15 genom.^[1]^[2]

Literatura

^ Heiber M, Marchese A, Nguyen T, Heng HH, George SR, O'Dowd BF (1997). „A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3”. Genomics. 32 (3): 462—5. PMID 8838812. doi:10.1006/geno.1996.0143.
^ „Entrez Gene: GPR15 G protein-coupled receptor 15”.

Dodatna literatura

Cunningham AL; Li S; Juarez J; et al. (2000). „The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes.”. J. Leukoc. Biol. 68 (3): 311—7. PMID 10985245. CS1 одржавање: Експлицитна употреба et al. (веза)
Deng HK, Unutmaz D, KewalRamani VN, Littman DR (1997). „Expression cloning of new receptors used by simian and human immunodeficiency viruses.”. Nature. 388 (6639): 296—300. PMID 9230441. doi:10.1038/40894.
Farzan M; Choe H; Martin K; et al. (1997). „Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection.”. J. Exp. Med. 186 (3): 405—11. PMC 2198994 . PMID 9236192. doi:10.1084/jem.186.3.405. CS1 одржавање: Експлицитна употреба et al. (веза)
Clayton F; Kotler DP; Kuwada SK; et al. (2001). „Gp120-induced Bob/GPR15 activation: a possible cause of human immunodeficiency virus enteropathy.”. Am. J. Pathol. 159 (5): 1933—9. PMC 1867054 . PMID 11696454. CS1 одржавање: Експлицитна употреба et al. (веза)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. CS1 одржавање: Експлицитна употреба et al. (веза)
Croitoru-Lamoury J; Guillemin GJ; Boussin FD; et al. (2003). „Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation.”. Glia. 41 (4): 354—70. PMID 12555203. doi:10.1002/glia.10181. CS1 одржавање: Експлицитна употреба et al. (веза)
Maresca M; Mahfoud R; Garmy N; et al. (2003). „The virotoxin model of HIV-1 enteropathy: involvement of GPR15/Bob and galactosylceramide in the cytopathic effects induced by HIV-1 gp120 in the HT-29-D4 intestinal cell line.”. J. Biomed. Sci. 10 (1): 156—66. PMID 12566994. doi:10.1159/000068089. CS1 одржавање: Експлицитна употреба et al. (веза)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504. CS1 одржавање: Експлицитна употреба et al. (веза)
Blaak H; Boers PH; Gruters RA; et al. (2005). „CCR5, GPR15, and CXCR6 are major coreceptors of human immunodeficiency virus type 2 variants isolated from individuals with and without plasma viremia.”. J. Virol. 79 (3): 1686—700. PMC 544080 . PMID 15650194. doi:10.1128/JVI.79.3.1686-1700.2005. CS1 одржавање: Експлицитна употреба et al. (веза)
Cilliers T; Willey S; Sullivan WM; et al. (2005). „Use of alternate coreceptors on primary cells by two HIV-1 isolates.”. Virology. 339 (1): 136—44. PMID 15992849. doi:10.1016/j.virol.2005.05.027. CS1 одржавање: Експлицитна употреба et al. (веза)

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)