Retinalni G protein spregnuti receptor

Retinalni G protein spregnuti receptor‎‎

Identifikatori

RGR;

Vanjski ID

OMIM: 600342 MGI: 1929473 HomoloGene: 37709 GeneCards: RGR Gene

Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • proteinsko vezivanje
Celularna komponenta	• integralno sa ćelijskom membranom • membrana • integralno sa membranom
Biološki proces	• prenos signala • signalni put G-protein spregnutog receptora • vizuelna percepcija • fototransdukcija • protein-hromofor veza • respons na stimulus

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

5995

57811

Ensembl

ENSG00000148604

ENSMUSG00000021804

UniProt

P47804

Q3UEX9

RefSeq (mRNA)

NM_001012720

NM_021340

RefSeq (protein)

NP_001012738

NP_067315

Lokacija (UCSC)

Chr 10:
85.99 - 86.01 Mb

Chr 14:
35.95 - 35.96 Mb

PubMed pretraga

[1]

[2]

Retinalni G protein spregnuti receptor je protein koji je kod čoveka kodiran RGR genom.^[1]^[2]

{{PBB_Summary | section_title = | summary_text = Defekti ovog gena su uzrok retinitis pigmentose. Oni mogu da se ispolje kao autosomalna recesivna ili dominantna retinitis pigmentosa (arRP i adRP, respektivno). Ovaj gen je član familije rodopsinu-sličnih receptora GPCR. Poput drugih opsina koji vezuju retinaldehid, on sadrži konzervirani lizin u svom sedmom transmembranskom domenu. Za ovaj protein se smatra da dejstvuje kao fotoizomeraza koja katalizuje konverziju sve-trans-retinala u 11-cis-retinal, slično retinohromu kod beskičmenjaka. Reverzna izomerizacija rodopsina se odvija u retinalnim fotoreceptorskim ćelijama. Ovaj protein je ekskluzivno izražen u tkivima koja su susedna retinalnim fotoreceptorskim ćelijama i retinalnom pigmentnom epitelu. Alternativno splajsovanje rezultuje u višestrukim transkriptnim varijantama koje kodiraju različite isoforme.^[2]

Interakcije

Za retinalni G protein spregnuti receptor je bilo pokazano da interaguje sa KIAA1279.^[3]

Reference

^ Chen XN, Korenberg JR, Jiang M, Shen D, Fong HK (1996). „Localization of the human RGR opsin gene to chromosome 10q23”. Hum Genet. 97 (6): 720—2. PMID 8641686. doi:10.1007/BF02346179.
^ ^а ^б „Entrez Gene: RGR retinal G protein coupled receptor”.
^ Rual, Jean-François; Kavitha, Venkatesan; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. England. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209.

Literatura

M, Jiang; D, Shen; L, Tao; et al. (1995). „Alternative splicing in human retinal mRNA transcripts of an opsin-related protein.”. Exp. Eye Res. 60 (4): 401—6. PMID 7789419. doi:10.1016/S0014-4835(05)80096-X.
D, Shen; M, Jiang; W, Hao; et al. (1994). „A human opsin-related gene that encodes a retinaldehyde-binding protein.”. Biochemistry. 33 (44): 13117—25. PMID 7947717. doi:10.1021/bi00248a022.
Morimura H, Saindelle-Ribeaudeau F, Berson EL, Dryja TP (1999). „Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa.”. Nat. Genet. 23 (4): 393—4. PMID 10581022. doi:10.1038/70496.
Chen P, Lee TD, Fong HK (2001). „Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal g protein-coupled receptor opsin.”. J. Biol. Chem. 276 (24): 21098—104. PMID 11274198. doi:10.1074/jbc.M010441200.
Yang M, Fong HK (2002). „Synthesis of the all-trans-retinal chromophore of retinal G protein-coupled receptor opsin in cultured pigment epithelial cells.”. J. Biol. Chem. 277 (5): 3318—24. PMID 11723126. doi:10.1074/jbc.M108946200.
RL, Strausberg; EA, Feingold; LH, Grouse; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Bellingham J, Wells DJ, Foster RG (2003). „In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolution.”. BMC Genomics. 4 (1): 3. PMC 149353 . PMID 12542842. doi:10.1186/1471-2164-4-3.
EE, Tarttelin; J, Bellingham; LC, Bibb; et al. (2003). „Expression of opsin genes early in ocular development of humans and mice.”. Exp. Eye Res. 76 (3): 393—6. PMID 12573668. doi:10.1016/S0014-4835(02)00300-7.
S, Bernal; M, Calaf; Garcia-Hoyos M; et al. (2003). „Study of the involvement of the RGR, CRPB1, and CRB1 genes in the pathogenesis of autosomal recessive retinitis pigmentosa.”. J. Med. Genet. 40 (7): e89. PMC 1735523 . PMID 12843338. doi:10.1136/jmg.40.7.e89.
DS, Gerhard; L, Wagner; EA, Feingold; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
JF, Rual; K, Venkatesan; T, Hao; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network.”. Nature. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209.
L, Zhu; Y, Imanishi; S, Filipek; et al. (2006). „Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene.”. J. Biol. Chem. 281 (31): 22289—98. PMC 1618956 . PMID 16737970. doi:10.1074/jbc.M602664200.
MY, Lin; H, Kochounian; RE, Moore; et al. (2007). „Deposition of exon-skipping splice isoform of human retinal G protein-coupled receptor from retinal pigment epithelium into Bruch's membrane.”. Mol. Vis. 13: 1203—14. PMID 17679941.

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)